ArticleMolecular carcinogenesis2010
Microarray analysis of cutaneous squamous cell carcinomas reveals enhanced expression of epidermal differentiation complex genes.
Article in Molecular carcinogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Transcriptomic Study on Human Skin Samples: Identification of Two Subclasses of Actinic Keratoses.International journal of molecular sciences · 2023Article
- Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma.International journal of molecular sciences · 2022Review
- Article
- Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors.Oncotarget · 2016Article
- Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.Nature communications · 2016Article
- Lgr5+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors.Oncotarget · 2016Article
- Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.British journal of cancer · 2016Article
- Transcriptome Analysis Identifies the Dysregulation of Ultraviolet Target Genes in Human Skin Cancers.PloS one · 2016Article
- TMEM45A, SERPINB5 and p16INK4A transcript levels are predictive for development of high-grade cervical lesions.American journal of cancer research · 2016Article
- Intra-ventral tegmental area HIV-1 Tat1-86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats.Frontiers in microbiology · 2015Article
- Differential expression of degradome components in cutaneous squamous cell carcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2014Article
- Gene expression profiling of the leading edge of cutaneous squamous cell carcinoma: IL-24-driven MMP-7.The Journal of investigative dermatology · 2014Article
- Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice.Molecular and cellular biology · 2013Article
- Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.BMC cancer · 2013Article
- Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?Scientific reports · 2013Article
- Article
- Distinct innate immune gene expression profiles in non-melanoma skin cancer of immunocompetent and immunosuppressed patients.PloS one · 2012Article
- Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling.PloS one · 2012Article
- Recombinant human immunodeficiency virus-1 transactivator of transcription1-86 allosterically modulates dopamine transporter activity.Synapse (New York, N.Y.) · 2011Article
- Genetically expressed HIV-1 viral proteins attenuate nicotine-induced behavioral sensitization and alter mesocorticolimbic ERK and CREB signaling in rats.Pharmacology, biochemistry, and behavior · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Gene expression profiles were determined for 12 cutaneous squamous cell carcinomas (SCC) removed from sun-exposed sites on nonimmunosuppressed patients. Gene expression in each SCC was compared to that in sun-exposed skin from the same patient using the Affymetrix HGU133 2.0 PlusGeneChip. We identified 440 genes with increased expression in SCC and 738 with decreased expression; overall we identified a large number of small changes in gene expression rather than a few marked changes that distinguished SCC from sun-exposed skin. Analyzing this robust data set according to biofunctional pathways using DAVID, transcriptional control elements using oPOSSUM, and chromosomal location using GSEA suggested genetic and epigenetic mechanisms of gene expression regulation in SCC. Some altered patterns of gene expression in SCC were consistent with regulation of spatially separated genes by a number of developmentally important transcription factors (forkhead, HMG, and homeo factors) that negatively regulated gene expression and to a few factors that positively regulated expression (Creb-1, NFkappaB, RelA, and Sp-1). We also found that coordinately enhanced expression of epidermal differentiation complex genes on chromosome 1q21 was a hallmark of SCC. A novel finding in our study was enhanced expression of keratin 13 in SCC, a result validated by immunohistochemical staining of an SCC tumor tissue array.
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