ReviewBiopolymers2010
Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms.
Review in Biopolymers, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Mycotoxins in Basidiomycete Mycelium and Fruiting Bodies: Implications for Eu Novel Food Assessment and Selected International Regulatory Frameworks.Comprehensive reviews in food science and food safety · 2026Review
- Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions.Archives of pharmacal research · 2024Review
- Subcellular localization of fungal specialized metabolites.Fungal biology and biotechnology · 2022Review
- SPI "sandwich": Combined SUMO-Peptide-Intein expression system and isolation procedure for improved stability and yield of peptides.Protein science : a publication of the Protein Society · 2022Article
- [Observation of dendrite osteocytes of mice at different developmental stages using Ploton silver staining and phalloidin staining].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Diversity of MSDIN family members in amanitin-producing mushrooms and the phylogeny of the MSDIN and prolyl oligopeptidase genes.BMC genomics · 2020Article
- Minimal lactazole scaffold for in vitro thiopeptide bioengineering.Nature communications · 2020Article
- A Convergent Total Synthesis of the Death Cap Toxin α-Amanitin.Angewandte Chemie (International ed. in English) · 2020Article
- Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products.Molecules (Basel, Switzerland) · 2019Review
- Combining microfluidics and RNA-sequencing to assess the inducible defensome of a mushroom against nematodes.BMC genomics · 2019Article
- The Biosynthesis of Heterophyllin B inFrontiers in plant science · 2019Article
- Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides.Biochemistry · 2018Review
- Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides.Molecules (Basel, Switzerland) · 2017Review
- Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.Nature communications · 2017Article
- Six Key Traits of Fungi: Their Evolutionary Origins and Genetic Bases.Microbiology spectrum · 2017Article
- The good, the bad and the tasty: The many roles of mushrooms.Studies in mycology · 2016Article
- Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Identification of a Novel Nematotoxic Protein by Challenging the Model Mushroom Coprinopsis cinerea with a Fungivorous Nematode.G3 (Bethesda, Md.) · 2015Article
- Long-Term Resistance of Drosophila melanogaster to the Mushroom Toxin Alpha-Amanitin.PloS one · 2015Article
- The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzyme.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Some species of mushrooms in the genus Amanita are extremely poisonous and frequently fatal to mammals including humans and dogs. Their extreme toxicity is due to amatoxins such as alpha- and beta-amanitin. Amanita mushrooms also biosynthesize a chemically related group of toxins, the phallotoxins, such as phalloidin. The amatoxins and phallotoxins (collectively known as the Amanita toxins) are bicyclic octa- and heptapeptides, respectively. Both contain an unusual Trp-Cys crossbridge known as tryptathionine. We have shown that, in Amanita bisporigera, the amatoxins and phallotoxins are synthesized as proproteins on ribosomes and not by nonribosomal peptide synthetases. The proproteins are 34-35 amino acids in length and have no predicted signal peptides. The genes for alpha-amanitin (AMA1) and phallacidin (PHA1) are members of a large family of related genes, characterized by highly conserved amino acid sequences flanking a hypervariable "toxin" region. The toxin regions are flanked by invariant proline (Pro) residues. An enzyme that could cleave the proprotein of phalloidin was purified from the phalloidin-producing lawn mushroom Conocybe apala. The enzyme is a serine protease in the prolyl oligopeptidase (POP) subfamily. The same enzyme cuts at both Pro residues to release the linear hepta- or octapeptide.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.