ArticleThe International journal of developmental biology2010
Developmental expression of Xenopus short-chain dehydrogenase/reductase 3.
Article in The International journal of developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Enhanced Loss of Retinoic Acid Network Genes inCells · 2022Article
- Disabled-2: a positive regulator of the early differentiation of myoblasts.Cell and tissue research · 2020Article
- Analysis of leaf morphology, secondary metabolites and proteins related to the resistance to Tetranychus cinnabarinus in cassava (Manihot esculenta Crantz).Scientific reports · 2020Article
- Developmental expression of threeZoological research · 2019Article
- Retinoic acid-induced expression ofDevelopment (Cambridge, England) · 2018Article
- New insights and changing paradigms in the regulation of vitamin A metabolism in development.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Dhrs3 protein attenuates retinoic acid signaling and is required for early embryonic patterning.The Journal of biological chemistry · 2013Article
- DHRS3, a retinal reductase, is differentially regulated by retinoic acid and lipopolysaccharide-induced inflammation in THP-1 cells and rat liver.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Retinoic acid synthesis and functions in early embryonic development.Cell & bioscience · 2012Article
- p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.The Journal of biological chemistry · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
During early embryonic development, the retinoic acid signaling pathway coordinates with other signaling pathways to regulate body axis patterning and organogenesis. The production of retinoic acid requires two enzymatic reactions, the first of which is the oxidization of vitamin A (all-trans-retinol) to all-trans -retinal, mediated in part by the short-chain dehydrogenase/reductase. Through DNA microarrays, we have identified a gene in Xenopus laevis which shares a high sequence similarity to human short-chain dehydrogenase/reductase member 3. We therefore annotated the gene Xenopus short-chain dehydrogenase/reductase 3 (dhrs3). Expression of dhrs3 was detected by whole mount in situ hybridization in the dorsal blastopore lip and axial mesoderm region in gastrula embryos. During neurulation, dhrs3 transcripts were found in the notochord and neural ectoderm. Strong expression of dhrs3 was mainly detected in the brain, spinal cord and pronephros region in tailbud and tadpole stages. Temporal expression tested by RT-PCR indicated that dhrs3 was activated at the onset of gastrulation, and remained highly expressed at later stages of embryonic development. The distinct and highly regulated spatial and temporal expression of dhrs3 highlights the complexity of retinoic acid regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.