ReviewJournal of neural transmission (Vienna, Austria : 1996)2010
The wearing-off phenomenon and the use of questionnaires to facilitate its recognition in Parkinson's disease.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Trial
- Treatment stability comparison among different ADD-ON therapies in fluctuating Parkinson's disease patients: the role of clinical and demographic factors.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Motor and non-motor fluctuations in Parkinson's disease: the knowns and unknowns of current therapeutic approaches.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- MSN Templated with L-Dopa Amide Derivatives Outperforms the Efficiency of Free-L-Dopa in Reducing Parkinson's Behavioral Dysfunction in Mice.International journal of nanomedicine · 2026Article
- Resting-state hippocampal asymmetry as a marker for memory and olfactory deficit in parkinson's disease.Scientific reports · 2025Article
- Article
- Impaired odor recognition memory in Parkinson's disease linked to absent functional hippocampal asymmetry.NPJ Parkinson's disease · 2025Article
- Early start of opicapone in Parkinson's disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations.Frontiers in neurology · 2025Article
- Sublingual apomorphine in the treatment of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Integrity of the nucleus basalis of meynert and self-reported cognitive dysfunction during wearing-off periods in parkinson's disease.Brain imaging and behavior · 2024Article
- Real-World Experiences of Parkinson's Disease OFF Time and Role of Demographics.Journal of patient-centered research and reviews · 2024Article
- Clinical Use of On-Demand Therapies for Patients with Parkinson's Disease and OFF Periods.Neurology and therapy · 2023Review
- Clinical benefit of MAO-B and COMT inhibition in Parkinson's disease: practical considerations.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- An Individualized Multi-Modal Approach for Detection of Medication "Off" Episodes in Parkinson's Disease via Wearable Sensors.Journal of personalized medicine · 2023Article
- Feasibility of a wearable inertial sensor to assess motor complications and treatment in Parkinson's disease.PloS one · 2023Observational
- 'Anxious fluctuators' a subgroup of Parkinson's disease with high anxiety and problematic on-off fluctuations.Parkinsonism & related disorders · 2022Article
- Sensor Measurements Can Characterize Fluctuations and Wearing Off in Parkinson's Disease and Guide Therapy to Improve Motor, Non-motor and Quality of Life Scores.Frontiers in aging neuroscience · 2022Article
- A method for measuring time spent in bradykinesia and dyskinesia in people with Parkinson's disease using an ambulatory monitor.Journal of neuroengineering and rehabilitation · 2021Article
- Assessment of Wearing Off in Parkinson's disease using objective measurement.Journal of neurology · 2021Article
- Patient perspectives on the therapeutic profile of botulinum neurotoxin type A in cervical dystonia.Journal of neurology · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term treatment of Parkinson's disease (PD) with dopaminergic therapy is associated with a re-emergence of PD symptoms, referred to as wearing-off. Signs of wearing-off encompass motor symptoms, such as slowness of movement and stiffness, and non-motor symptoms, including anxiety and fatigue. Both motor and non-motor symptoms impact significantly on the function and quality of life of PD patients. Early detection and management of wearing-off has been shown to improve patient symptoms; however, identification of wearing-off, particularly the non-motor symptoms, is hampered by a lack of patient education, awareness, patient-physician communication, and limited time for evaluation. Several questionnaires have been developed to aid the detection of wearing-off. This review investigates the development and use of the Wearing-Off Questionnaires (WOQ-32, WOQ-19, and WOQ-9), as well as their sensitivity and specificity in identifying wearing-off. The manuscript also provides an overview of the motor and non-motor signs of wearing-off and highlights the available treatment strategies for managing this potentially debilitating phenomenon.
Indexed as
Identifiers
20563826What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.