ArticleTranslational stroke research2010
Is there a place for cerebral preconditioning in the clinic?
Article in Translational stroke research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Ischemic Conditioning Is Safe and Effective for Octo- and Nonagenarians in Stroke Prevention and Treatment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Trial
- Sirtuin 1 Mediates Protection Against Delayed Cerebral Ischemia in Subarachnoid Hemorrhage in Response to Hypoxic Postconditioning.Journal of the American Heart Association · 2021Article
- Refocusing the Brain: New Approaches in Neuroprotection Against Ischemic Injury.Neurochemical research · 2021Review
- The Neuronal Ischemic Tolerance Is Conditioned by the Tp53 Arg72Pro Polymorphism.Translational stroke research · 2019Article
- SIRT1 Activation: A Potential Strategy for Harnessing Endogenous Protection Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.Neurosurgery · 2018Article
- Progress in AQP Research and New Developments in Therapeutic Approaches to Ischemic and Hemorrhagic Stroke.International journal of molecular sciences · 2016Review
- Full steam ahead with remote ischemic conditioning for stroke.Translational stroke research · 2014Article
- Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance.Progress in neurobiology · 2014Review
- Immune mechanisms in cerebral ischemic tolerance.Frontiers in neuroscience · 2014Review
- Should the STAIR criteria be modified for preconditioning studies?Translational stroke research · 2013Article
- Ischemic preconditioning attenuates brain edema after experimental intracerebral hemorrhage.Translational stroke research · 2012Article
- Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Hyperbaric oxygen for cerebral vasospasm and brain injury following subarachnoid hemorrhage.Translational stroke research · 2011Article
- Protective conditioning of the brain: expressway or roadblock?The Journal of physiology · 2011Article
- Article
- Thrombin-induced neuronal protection: role of the mitogen activated protein kinase/ribosomal protein S6 kinase pathway.Brain research · 2010Article
- Clinical translation of cerebral preconditioning.Translational stroke research · 2010Article
- Commentary on: "Effect of sevoflurane anesthesia on the comprehensive mRNA expression profile of the mouse hippocampus":Medical gas researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Preconditioning (PC) describes a phenomenon whereby a sub-injury inducing stress can protect against a later injurious stress. Great strides have been made in identifying the mechanisms of PC-induced protection in animal models of brain injury. While these may help elucidate potential therapeutic targets, there are questions over the clinical utility of cerebral PC, primarily because of questions over the need to give the PC stimulus prior to the injury, narrow therapeutic windows and safety. The object of this review is to address the question of whether there may indeed be a clinical use for cerebral PC and to discuss the deficiencies in our knowledge of PC that may hamper such clinical translation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.