ArticleNeoplasia (New York, N.Y.)2010
Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner.
Article in Neoplasia (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Cathepsins and Skin Cancer (Malignant Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma): Insight From Genetic Correlation and Mendelian Randomization.Clinical, cosmetic and investigational dermatology · 2025Article
- A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma.International journal of cancer · 2022Article
- Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testing.Scientific reports · 2021Article
- Cathepsin B is highly expressed in pancreatic cancer stem-like cells and is associated with patients' surgical outcomes.Oncology letters · 2021Article
- AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking.Neoplasia (New York, N.Y.) · 2018Article
- Cathepsins in digestive cancers.Oncotarget · 2017Review
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- Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity.Oncotarget · 2015Article
- Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies.Biological chemistry · 2015Article
- SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells.Molecular cancer · 2015Article
- TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.Experimental cell research · 2015Article
- Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma.Carcinogenesis · 2014Article
- Regulation of TGF-β1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C.The Journal of biological chemistry · 2014Article
- Cathepsin B: multiple roles in cancer.Proteomics. Clinical applications · 2014Review
- Epithelial-mesenchymal co-culture model for studying alveolar morphogenesis.Organogenesis · 2014Article
- Detection of esophageal squamous cell carcinoma by cathepsin B activity in nude mice.PloS one · 2014Article
- Cathepsins mediate tumor metastasis.World journal of biological chemistry · 2013Review
- Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype.Journal of experimental & clinical cancer research : CR · 2013Article
- Overexpression of cystatin SN positively affects survival of patients with surgically resected esophageal squamous cell carcinoma.BMC surgery · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Esophageal cancer, which frequently exhibits coordinated loss of E-cadherin (Ecad) and transforming growth factor beta (TGFbeta) receptor II (TbetaRII), has a high mortality rate. In a three-dimensional organotypic culture model system, esophageal keratinocytes expressing dominant-negative mutant versions of both Ecad and TbetaRII (ECdnT) invade into the underlying matrix embedded with fibroblasts. We also find that cathepsin B induction is necessary for fibroblast-mediated invasion. Furthermore, the ECdnT cells in this physiological context activate fibroblasts through the secretion of TGFbeta1, which, in turn, is activated by cathepsin B. These results suggest that the interplay between the epithelial compartment and the surrounding microenvironment is crucial to invasion into the extracellular matrix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.