ArticleNature physics2010
Optimal matrix rigidity for stress fiber polarization in stem cells.
Article in Nature physics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.
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Who cites it
160 citing papers in PubMed.
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- Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population.PLoS computational biology · 2026Article
- Fiber recruitment drives a phase transition of cell polarization at a critical cell spacing in matrix-mediated tissue remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Combined stimuli of elasticity and microgrooves form aligned myotubes that characterize slow twitch muscles.Scientific reports · 2025Article
- Dynamic stimulation promotes functional tissue-like organization of a 3D human lymphoid microenvironment model in vitro.Cell reports methods · 2025Article
- Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos.ArXiv · 2025Article
- Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos.bioRxiv : the preprint server for biology · 2025Article
- Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity.Nature communications · 2025Article
- Capturing the mechanosensitivity of cell proliferation in models of epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Elastic interactions compete with persistent cell motility to drive durotaxis.Biophysical journal · 2024Article
- Mechanosensitive Differentiation of Human iPS Cell-Derived Podocytes.Bioengineering (Basel, Switzerland) · 2024Article
- Architecture-driven quantitative nanoscopy maps cytoskeleton remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reversible Host-Guest Crosslinks in Supramolecular Hydrogels for On-Demand Mechanical Stimulation of Human Mesenchymal Stem Cells.Advanced healthcare materials · 2024Article
- Optimization of H9c2 differentiation leads to calcium-active and striated cardiac cells without addition of retinoic acid.Frontiers in cell and developmental biology · 2024Article
- Optimal mechanical interactions direct multicellular network formation on elastic substrates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots.Communications biology · 2023Article
- Metal-Induced Energy Transfer (MIET) for Live-Cell Imaging with Fluorescent Proteins.ACS nano · 2023Article
- Tracing and tracking filamentous structures across scales: A systematic review.Computational and structural biotechnology journal · 2023Review
- FilamentSensor 2.0: An open-source modular toolbox for 2D/3D cytoskeletal filament tracking.PloS one · 2023Article
100 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The shape and differentiation of human mesenchymal stem cells is especially sensitive to the rigidity of their environment; the physical mechanisms involved are unknown. A theoretical model and experiments demonstrate here that the polarization/alignment of stress-fibers within stem cells is a non-monotonic function of matrix rigidity. We treat the cell as an active elastic inclusion in a surrounding matrix whose polarizability, unlike dead matter, depends on the feedback of cellular forces that develop in response to matrix stresses. The theory correctly predicts the monotonic increase of the cellular forces with the matrix rigidity and the alignment of stress-fibers parallel to the long axis of cells. We show that the anisotropy of this alignment depends non-monotonically on matrix rigidity and demonstrate it experimentally by quantifying the orientational distribution of stress-fibers in stem cells. These findings offer a first physical insight for the dependence of stem cell differentiation on tissue elasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.