ArticleNature methods2010
Noncontact microrheology at acoustic frequencies using frequency-modulated atomic force microscopy.
Article in Nature methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Combined AAV-mediated gene replacement therapy improves auditory function in a mouse model of human DFNB42 deafness.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- 3D nanomechanical mapping of subcellular and sub-nuclear structures of living cells by multi-harmonic AFM with long-tip microcantilevers.Scientific reports · 2022Article
- Myosin II isoforms promote internalization of spatially distinct clathrin-independent endocytosis cargoes through modulation of cortical tension downstream of ROCK2.Molecular biology of the cell · 2021Article
- Computational Image Analysis of Guided Acoustic Waves Enables Rheological Assessment of Sub-nanoliter Volumes.ACS nano · 2019Article
- The Tectorial Membrane: Mechanical Properties and Functions.Cold Spring Harbor perspectives in medicine · 2019Review
- Unified cochlear model for low- and high-frequency mammalian hearing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.Science advances · 2019Article
- Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections.Physical review letters · 2019Article
- Apical surface supracellular mechanical properties in polarized epithelium using noninvasive acoustic force spectroscopy.Nature communications · 2017Article
- High-frequency microrheology reveals cytoskeleton dynamics in living cells.Nature physics · 2017Article
- Geometric Requirements for Tectorial Membrane Traveling Waves in the Presence of Cochlear Loads.Biophysical journal · 2017Article
- Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta.Journal of the mechanical behavior of biomedical materials · 2016Article
- Combined strategies for optimal detection of the contact point in AFM force-indentation curves obtained on thin samples and adherent cells.Scientific reports · 2016Article
- Longitudinal spread of mechanical excitation through tectorial membrane traveling waves.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Basilar membrane and tectorial membrane stiffness in the CBA/CaJ mouse.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Porosity controls spread of excitation in tectorial membrane traveling waves.Biophysical journal · 2014Article
- Phase of shear vibrations within cochlear partition leads to activation of the cochlear amplifier.PloS one · 2014Article
- Article
- Determination of the elastic moduli of thin samples and adherent cells using conical atomic force microscope tips.Nature nanotechnology · 2012Article
- Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea.Development (Cambridge, England) · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We report an atomic force microscopy (AFM) method for assessing elastic and viscous properties of soft samples at acoustic frequencies under non-contact conditions. The method can be used to measure material properties via frequency modulation and is based on hydrodynamics theory of thin gaps we developed here. A cantilever with an attached microsphere is forced to oscillate tens of nanometers above a sample. The elastic modulus and viscosity of the sample are estimated by measuring the frequency-dependence of the phase lag between the oscillating microsphere and the driving piezo at various heights above the sample. This method features an effective area of pyramidal tips used in contact AFM but with only piconewton applied forces. Using this method, we analyzed polyacrylamide gels of different stiffness and assessed graded mechanical properties of guinea pig tectorial membrane. The technique enables the study of microrheology of biological tissues that produce or detect sound.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.