ArticleNature structural & molecular biology2010
Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing.
Article in Nature structural & molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 110 citations in OpenAlex.
- ISWI catalyzes nucleosome sliding in condensed nucleosome arrays.bioRxiv : the preprint server for biology · 2023Article
- Article
- Fibrosis-the tale of H3K27 histone methyltransferases and demethylases.Frontiers in cell and developmental biology · 2023Review
- Of numbers and movement - understanding transcription factor pathogenesis by advanced microscopy.Disease models & mechanisms · 2020Review
- Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Review
- Functional Significance of Satellite DNAs: Insights FromFrontiers in cell and developmental biology · 2020Review
- JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila.Nature communications · 2019Article
- Determination of Chromatin Accessibility inBio-protocol · 2019Article
- Article
- NOMePlot: analysis of DNA methylation and nucleosome occupancy at the single molecule.Scientific reports · 2019Article
- Ant behaviour and brain gene expression of defending hosts depend on the ecological success of the intruding social parasite.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Chromatin folding and nuclear architecture: PRC1 function in 3D.Current opinion in genetics & development · 2019Review
- Article
- Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation inGenome research · 2018Article
- Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.Genome research · 2018Article
- Transcriptional modulation of entire chromosomes: dosage compensation.Journal of genetics · 2018Review
- Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis.The EMBO journal · 2017Article
- DNA Replication Control DuringGenetics · 2017Review
- Genome-wide Single-Molecule Footprinting Reveals High RNA Polymerase II Turnover at Paused Promoters.Molecular cell · 2017Article
- Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation.Molecular cell · 2017Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone modifications are thought to regulate gene expression in part by modulating DNA accessibility. Here, we measured genome-wide DNA accessibility in Drosophila melanogaster by combining M.SssI methylation footprinting with methylated DNA immunoprecipitation. We show that methylase accessibility demarcates differential distribution of active and repressive histone modifications as well as sites of transcription and replication initiation. DNA accessibility is increased at active promoters and chromosomal regions that are hyperacetylated at H4K16, particularly at the male X chromosome, suggesting that transcriptional dosage compensation is facilitated by permissive chromatin structure. Conversely, inactive chromosomal domains decorated with H3K27me3 are least accessible, supporting a model for Polycomb-mediated chromatin compaction. In addition, we detect higher accessibility at chromosomal regions that replicate early and at sites of replication initiation. Together, these findings indicate that differential histone-modification patterns and the organization of replication have distinct and measurable effects on the exposure of the DNA template.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.