ArticleJournal of lipid research2010
Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
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- Integrative Analyses RevealCells · 2021Article
- Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice.The Journal of biological chemistry · 2018Article
- A Bivariate Hypothesis Testing Approach for Mapping the Trait-Influential Gene.Scientific reports · 2017Article
- Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress.The Journal of biological chemistry · 2017Article
- Obesity-induced endoplasmic reticulum stress suppresses nuclear factor-Y expression.Molecular and cellular biochemistry · 2017Article
- Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice.Cholesterol · 2017Article
- A forest-based feature screening approach for large-scale genome data with complex structures.BMC genetics · 2015Article
- A graphical weighted power improving multiplicity correction approach for SNP selections.Current genomics · 2014Article
- Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection.PloS one · 2014Article
- Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in I/LnJ mice.G3 (Bethesda, Md.) · 2013Article
- Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9.Lipids in health and disease · 2013Article
- Genome-wide association mapping of quantitative traits in outbred mice.G3 (Bethesda, Md.) · 2012Article
- The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol.Journal of lipid research · 2011Article
- Combining genome-wide data from humans and animal models of dyslipidemia and atherosclerosis.Current opinion in lipidology · 2011Review
- Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross.Molecular painArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Two high-density lipoprotein cholesterol quantitative trait loci (QTL), Hdlq1 at 125 Mb and Hdlq8 at 113 Mb, were previously identified on mouse distal chromosome 5. Our objective was to identify the underlying genes. We first used bioinformatics to narrow the Hdlq1 locus to 56 genes. The most likely candidate, Scarb1 (scavenger receptor B1), was supported by gene expression data consistent with knockout and transgenic mouse models. Then we confirmed Hdlq8 as an independent QTL by detecting it in an intercross between NZB and NZW (LOD = 12.7), two mouse strains that have identical genotypes for Scarb1. Haplotyping narrowed this QTL to 9 genes; the most likely candidate was Acads (acyl-coenzymeA dehydrogenase, short chain). Sequencing showed that Acads had an amino acid polymorphism, Gly94Asp, in a conserved region; Western blotting showed that protein levels were significantly different between parental strains. A previously known spontaneous deletion causes loss of ACADS activity in BALB/cBy mice. We showed that HDL levels were significantly elevated in BALB/cBy compared with BALB/c mice and that this HDL difference cosegregated with the Acads mutation. We confirmed that Hdlq1 and Hdlq8 are independent QTL on mouse chromosome 5 and demonstrated that Scarb1 and Acads are the underlying genes.
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