ArticleApplied and environmental microbiology2010
Differential regulation of six heavy metal efflux systems in the response of Myxococcus xanthus to copper.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- HME, NFE, and HAE-1 efflux pumps in Gram-negative bacteria: a comprehensive phylogenetic and ecological approach.ISME communications · 2024Article
- Review
- Antimicrobial Activity of Metals and Metalloids.Annual review of microbiology · 2021Review
- Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.Chemical reviews · 2021Review
- Copper and Melanin Play a Role inFrontiers in microbiology · 2020Article
- Metal-responsive RNA polymerase extracytoplasmic function (ECF) sigma factors.Molecular microbiology · 2019Review
- In depth analysis of the mechanism of action of metal-dependent sigma factors: characterization of CorE2 from Myxococcus xanthus.Nucleic acids research · 2016Article
- Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus.BMC genomics · 2014Article
- Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor.BMC microbiology · 2013Article
- Article
- Comprehensive set of integrative plasmid vectors for copper-inducible gene expression in Myxococcus xanthus.Applied and environmental microbiology · 2012Article
- CorE from Myxococcus xanthus is a copper-dependent RNA polymerase sigma factor.PLoS genetics · 2011Article
- Expression and physiological role of three Myxococcus xanthus copper-dependent P1B-type ATPases during bacterial growth and development.Applied and environmental microbiology · 2010Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myxococcus xanthus has to cope with changes in its environment during growth and development. Among these factors, the concentration of copper is crucial due to the essential toxic effect of this metal, which forces the cells to maintain a tight homeostasis. The M. xanthus copper response is more complex than that in other bacteria, which is reflected by the different copper sensitivities of growing and developing cells. In the present study, the participation in copper homeostasis of six heavy metal efflux systems encoded in the M. xanthus genome has been examined. Three of these pumps exhibit the signature sequences in transmembrane domain 4 of the Cus systems (Cus1, Cus2, and Cus3), while the other three exhibit the motifs of the Czc systems (Czc1, Czc2, and Czc3). The Cus2 and Cus3 systems are inducible by copper and monovalent metals, functioning as the main copper efflux pumps, while the Cus1 system is implicated in Zn(2+) homeostasis. The Czc systems are also differentially regulated either by divalent metals but not by copper (Czc1), by copper and divalent metals (Czc2), or by starvation (Czc3). The differential regulation of these six efflux systems ensures the proper completion of the M. xanthus life cycle in an environment with fluctuating concentrations of copper and other metals.
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