Evidence map›Paper›PMID 20562268›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2010

Understanding latent tuberculosis: a moving target.

Philana Ling Lin, Joanne L Flynn

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04526613 (A Cross-Sectional Study to Estimate the Influence of Malnutrition, Diabetes Mellitus and Helminth Infections on Biosignatures in Latent Tuberculosis in a South Indian Population), which is not on this map. Cited by 236 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed, 4 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04526613 completednot on this mapstarted 2021, after this paper: background citation

A Cross-Sectional Study to Estimate the Influence of Malnutrition, Diabetes Mellitus and Helminth Infections on Biosignatures in Latent Tuberculosis in a South Indian Population

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2021 to 2026Enrolled626ConditionsMycobacterium Tuberculosis, LTBI (Latent TB Infection), Malnutrition, Diabetes Mellitus
3 · Its place in the literature

Who cites it

236 citing papers in PubMed, 4 syntheses or guidelines pooled it, 479 citations in OpenAlex.

  1. Pooled it
  2. Pathology of TB/COVID-19 Co-Infection: The phantom menace.Tuberculosis (Edinburgh, Scotland) · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Compartment-specific inflammation in tuberculous lymphadenitis: a case-control study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Total Synthesis ofJournal of the American Chemical Society · 2026
    Article
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  15. Article
  16. Article
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  19. Review
  20. Review

176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Philana Ling LinDepartment of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
Joanne L Flynn
Children's Hospital of Pittsburgh · USUniversity of Pittsburgh · US

Funding

Cell Migration in Tuberculosis InfectionR01HL071241 · NHLBI · YESHIVA UNIVERSITY · PI CHAN, JOHN R. · 2002 to 2011
$4.8M
CD4 T Cells in TuberculosisR01AI050732 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 2002 to 2013
$4.8M
Latent and Reactivation TuberculosisR01HL075845 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 2003 to 2007
$3.3M
FUNCTION OF CD8T CELLS IN TUBERCULOSISR01AI037859 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 1997 to 2012
$3.2M
Defining how the spectrum of latency affects reactivation of TBR01HL106804 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2010 to 2013
$2.6M
A Multi-scale and Multi-system Approach to Understand Granuloma Formation in TBR33HL092883 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 2008 to 2010
$672k
TNF and Granuloma Formation in TuberculosisK08AI063101 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIN, PHILANA LING · 2005 to 2009
$584k
FUNCTION OF CD8 T CELLS IN TUBERCULOSISR21AI037859 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 1996 to 1996
–
NHLBI NIH HHS HL075845NHLBI NIH HHS HL092883NHLBI NIH HHS HL71241NHLBI NIH HHS R01 HL071241NHLBI NIH HHS R01 HL075845NHLBI NIH HHS R01 HL106804NHLBI NIH HHS R33 HL092883NIAID NIH HHS AI063101NIAID NIH HHS AI37859NIAID NIH HHS AI50732NIAID NIH HHS K08 AI063101NIAID NIH HHS R01 AI037859NIAID NIH HHS R01 AI050732
6 · The paper itself

Abstract

Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection. Latently infected persons, of which there are estimated to be approximately 2 billion in the world, represent an enormous reservoir of potential reactivation TB, which can spread to other people. The immunology of TB is complex and multifaceted. Identifying the immune mechanisms that lead to control of initial infection and prevent reactivation of latent infection is crucial to combating this disease.

Indexed as

Adaptive ImmunityAnimalsDisease Models, AnimalHumansImmunity, CellularImmunity, InnateLatent TuberculosisMycobacterium tuberculosis

Identifiers

PMID20562268
PMCPMC3311959
OpenAlexW1938351738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.