SynthesisEnvironmental health perspectives2010
Research recommendations for selected IARC-classified agents.
Synthesis in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Occupational Lead Exposure and Brain Tumors: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Occupational Lead Exposure and Associations with Selected Cancers: The Shanghai Men's and Women's Health Study Cohorts.Environmental health perspectives · 2016Pooled it
- Trichloroethylene and cancer: systematic and quantitative review of epidemiologic evidence for identifying hazards.International journal of environmental research and public health · 2011Pooled it
- Ameliorative Effects of Urolithin A Against Cadmium-Induced NLRP3-Mediated Pyroptosis and Cognitive Deficits Via Regulating Aryl Hydrocarbon Receptor Signaling.Biological trace element research · 2026Article
- Five decades of occupational cancer epidemiology.Scandinavian journal of work, environment & health · 2024Review
- Critical reviews of exposure assessment in carcinogenic hazard identification: the IARCOccupational and environmental medicine · 2024Review
- Exposure and Health Risks Posed by Potentially Toxic Elements in Soils of Metal Fabrication Workshops in Mbarara City, Uganda.Journal of xenobiotics · 2024Article
- Application of the Key Characteristics Framework to Identify Potential Breast Carcinogens Using Publicly AvailableEnvironmental health perspectives · 2024Article
- Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations.Environmental health perspectives · 2023Article
- Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.Environmental health perspectives · 2023Review
- What is next for occupational cancer epidemiology?Scandinavian journal of work, environment & health · 2022Article
- Lung cancer incidence among workers biologically monitored for occupational exposure to lead: a cohort study.Scandinavian journal of work, environment & health · 2022Article
- Editorial: Particles and Health 2021: An international conference addressing issues in science and regulation.Frontiers in public health · 2022Article
- Electronic nicotine delivery systems (ENDS): not still ready to put on END.Journal of thoracic disease · 2020Review
- Chemical Characterization of Seasonal PMInternational journal of environmental research and public health · 2020Article
- Effects of Heavy Metal Exposure on Shipyard Welders: A Cautionary Note for 8-Hydroxy-2'-Deoxyguanosine.International journal of environmental research and public health · 2019Article
- Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review.Environmental health and preventive medicine · 2019Review
- Environmental health surveillance in a future European health information system.Archives of public health = Archives belges de sante publique · 2018Article
- Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption.The Science of the total environment · 2017Review
- Evaluation of apoptosis induced by exposure to antineoplastic drugs in peripheral blood lymphocytes of nurses.Molecular medicine reports · 2017Article
Corrections and comments
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Authors and funding
33 authors.
Funding
Abstract
objectivesThere are some common occupational agents and exposure circumstances for which evidence of carcinogenicity is substantial but not yet conclusive for humans. Our objectives were to identify research gaps and needs for 20 agents prioritized for review based on evidence of widespread human exposures and potential carcinogenicity in animals or humans. DATA SOURCES: For each chemical agent (or category of agents), a systematic review was conducted of new data published since the most recent pertinent International Agency for Research on Cancer (IARC) Monograph meeting on that agent. DATA EXTRACTION: Reviewers were charged with identifying data gaps and general and specific approaches to address them, focusing on research that would be important in resolving classification uncertainties. An expert meeting brought reviewers together to discuss each agent and the identified data gaps and approaches. DATA SYNTHESIS: Several overarching issues were identified that pertained to multiple agents; these included the importance of recognizing that carcinogenic agents can act through multiple toxicity pathways and mechanisms, including epigenetic mechanisms, oxidative stress, and immuno- and hormonal modulation.
conclusionsStudies in occupational populations provide important opportunities to understand the mechanisms through which exogenous agents cause cancer and intervene to prevent human exposure and/or prevent or detect cancer among those already exposed. Scientific developments are likely to increase the challenges and complexities of carcinogen testing and evaluation in the future, and epidemiologic studies will be particularly critical to inform carcinogen classification and risk assessment processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.