ReviewNeurobiology of disease2010
Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.
Review in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- Dietary Interventions Modulate Cell Competition and Locomotor Decline in an Alzheimer's DiseaseCells · 2025Article
- A phenotypically robust model of spinal and bulbar muscular atrophy in Drosophila.Journal of neuroscience research · 2024Article
- Article
- Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition.Molecules (Basel, Switzerland) · 2022Review
- Drosophila as a Suitable In Vivo Model in the Safety Assessment of Nanomaterials.Advances in experimental medicine and biology · 2022Article
- Insects as a New Complex Model in Hormonal Basis of Obesity.International journal of molecular sciences · 2021Review
- Cell competition from development to neurodegeneration.Disease models & mechanisms · 2021Review
- MiR-3613-3p inhibits hypertrophic scar formation by down-regulating arginine and glutamate-rich 1.Molecular and cellular biochemistry · 2021Article
- Machine Learning Representation of Loss of Eye Regularity in aFrontiers in neuroscience · 2020Article
- Article
- Genetic human prion disease modelled in PrP transgenicThe Biochemical journal · 2017Article
- Role of MicroRNA Let-7 in Modulating Multifactorial Aspect of Neurodegenerative Diseases: an Overview.Molecular neurobiology · 2016Review
- Quantifying and predicting Drosophila larvae crawling phenotypes.Scientific reports · 2016Article
- The Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila.BMC neuroscience · 2016Article
- Article
- Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology.Human molecular genetics · 2015Article
- An automated image analysis method to measure regularity in biological patterns: a case study in a Drosophila neurodegenerative model.Molecular neurodegeneration · 2015Article
- Glia are critical for the neuropathology of complex I deficiency in Drosophila.Human molecular genetics · 2014Article
- Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2).Molecular neurodegeneration · 2014Article
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3 authors.
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Abstract
Neurodegenerative diseases encompass a large group of neurological disorders. Clinical symptoms can include memory loss, cognitive impairment, loss of movement or loss of control of movement, and loss of sensation. Symptoms are typically adult onset (although severe cases can occur in adolescents) and are reflective of neuronal and glial cell loss in the central nervous system. Neurodegenerative diseases also are considered progressive, with increased severity of symptoms over time, also reflective of increased neuronal cell death. However, various neurodegenerative diseases differentially affect certain brain regions or neuronal or glial cell types. As an example, Alzheimer disease (AD) primarily affects the temporal lobe, whereas neuronal loss in Parkinson disease (PD) is largely (although not exclusively) confined to the nigrostriatal system. Neuronal loss is almost invariably accompanied by abnormal insoluble aggregates, either intra- or extracellular. Thus, neurodegenerative diseases are categorized by (a) the composite of clinical symptoms, (b) the brain regions or types of brain cells primarily affected, and (c) the types of protein aggregates found in the brain. Here we review the methods by which Drosophila melanogaster has been used to model aspects of polyglutamine diseases, Parkinson disease, and amyotrophic lateral sclerosis and key insights into that have been gained from these models; Alzheimer disease and the tauopathies are covered elsewhere in this special issue.
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