ArticleOphthalmology2010
Relationship between optical coherence tomography retinal parameters and visual acuity in diabetic macular edema.
Article in Ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy.The Cochrane database of systematic reviews · 2015Pooled it
- Hard exudates in diabetic macular edema after intravitreal anti-VEGF therapy: a post-hoc analysis of the DRCR protocol T trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Trial
- Retinal Fluid Volatility Associated With Interval Tolerance and Visual Outcomes in Diabetic Macular Edema in the VISTA Phase III Trial.American journal of ophthalmology · 2021Trial
- Bevacizumab versus triamcinolone for persistent diabetic macular edema: a randomized clinical trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Trial
- Higher-Order Assessment of OCT in Diabetic Macular Edema from the VISTA Study: Ellipsoid Zone Dynamics and the Retinal Fluid Index.Ophthalmology. Retina · 2019Trial
- Assessment of differential pharmacodynamic effects using optical coherence tomography in neovascular age-related macular degeneration.Investigative ophthalmology & visual science · 2012Trial
- Imaging biomarkers in diabetic macular oedema: Predicting vision beyond retinal thickness.Eye (London, England) · 2026Article
- Assessment of area and structural irregularity of retinal layers in diabetic retinopathy using machine learning and image processing techniques.Scientific reports · 2024Article
- Exploring the role of retinal fluid as a biomarker for the management of diabetic macular oedema.Eye (London, England) · 2024Review
- Prediction of visual impairment in retinitis pigmentosa using deep learning and multimodal fundus images.The British journal of ophthalmology · 2023Article
- Pathological Neurovascular Unit Mapping onto Multimodal Imaging in Diabetic Macular Edema.Medicina (Kaunas, Lithuania) · 2023Review
- Automated assessment of the smoothness of retinal layers in optical coherence tomography images using a machine learning algorithm.BMC medical imaging · 2023Article
- Computer-aided detection and abnormality score for the outer retinal layer in optical coherence tomography.The British journal of ophthalmology · 2022Article
- Correlation between Choroidal Vascularity Index and Outer Retina in Patients with Diabetic Retinopathy.Journal of clinical medicine · 2022Article
- Article
- Müller Glial Expression of REDD1 Is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice.Diabetes · 2022Article
- Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema.World journal of diabetes · 2021Review
- Challenges in Diabetic Macular Edema Management: An Expert Consensus Report.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Optical Coherence Tomography Parameters Related to Vision Impairment in Patients with Diabetic Macular Edema: A Quantitative Correlation Analysis.Journal of ophthalmology · 2020Article
- Association between disorganization of retinal inner layers and visual acuity after proliferative diabetic retinopathy surgery.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeTo investigate the relationship between optical coherence tomography (OCT)-derived measurements of retinal morphology and visual acuity in patients with diabetic macular edema.
designRetrospective cross-sectional study.
participantsA total of 67 consecutive patients (67 eyes) with diabetic macular edema (DME) who underwent Stratus OCT imaging (Carl Zeiss Meditec, Inc., Dublin, CA).
methodsBest-corrected Snellen visual acuity was recorded for each patient. Raw exported Stratus OCT images for each patient were analyzed using custom software entitled "OCTOR," which allows the precise positioning of prespecified boundaries on individual B-scans. Thickness, volume, and intensity were calculated for neurosensory retina and subretinal fluid. In addition, photoreceptor outer segment (POS) thickness was quantified.
main outcome measuresOptical coherence tomography-derived measurements of retinal morphology and visual acuity.
resultsThe Spearman coefficient values (r) of the correlation between OCTOR-derived measurements of central subfield thickness, intensity, subretinal fluid volume, and POS thickness and the logarithm of the minimum angle of resolution visual acuities were 0.3428 (P = 0.005), -0.2658 (P = 0.03), -0.2683 (P = 0.38), and -0.3703 (P = 0.002), respectively. Multivariate models with stepwise selection revealed a cumulative R(2) of 0.4305 in the total study population, with R(2) of 0.4999 and 0.7628 in the untreated and prior focal laser groups, respectively.
conclusionsSubanalysis and quantification of OCT features in eyes with DME seem to be of value. In particular, POS thickness seems to be an important predictor of function and visual acuity in patients with DME.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.