Evidence map›Paper›PMID 20561356›Full record

ReviewImmunology2010

Inflammation in neurodegenerative diseases.

Sandra Amor, Fabiola Puentes, David Baker, Paul van der Valk

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06529744 (Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling), which is not on this map. Cited by 671 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
671citing papers in PubMed, 5 pooled it
46.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06529744 recruitingnot on this mapstarted 2023, after this paper: background citation

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

Typeobservational_patient_registrySponsorUniversity Health Network, TorontoRan2023 to 2027Enrolled500ConditionsDementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia
3 · Its place in the literature

Who cites it

671 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,347 citations in OpenAlex.

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  13. Comprehensive immunological and molecular analysis revealed inflammation-related diagnostic signatures in chronic rhinosinusitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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611 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sandra AmorDepartment of Pathology, VU University Medical Centre De Boelelaan, Amsterdam, the Netherlands. s.amor@vumc.nl
Fabiola Puentes
David Baker
Paul van der Valk
Queen Mary University of London · GBAmsterdam UMC Location VUmc · NL

Funding

Multiple Sclerosis Society 835Multiple Sclerosis Society 855
6 · The paper itself

Abstract

Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in the central nervous system, is the primary pathological feature of acute and chronic neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, neurotropic viral infections, stroke, paraneoplastic disorders, traumatic brain injury and multiple sclerosis. Despite different triggering events, a common feature is chronic immune activation, in particular of microglia, the resident macrophages of the central nervous system. Apart from the pathogenic role of immune responses, emerging evidence indicates that immune responses are also critical for neuroregeneration. Here, we review the impact of innate and adaptive immune responses on the central nervous system in autoimmune, viral and other neurodegenerative disorders, and discuss their contribution to either damage or repair. We also discuss potential therapies aimed at the immune responses within the central nervous system. A better understanding of the interaction between the immune and nervous systems will be crucial to either target pathogenic responses, or augment the beneficial effects of immune responses as a strategy to intervene in chronic neurodegenerative diseases.

Indexed as

ImmunotherapyInflammationAdaptive ImmunityAnimalsHumansImmunity, InnateMicrogliaModels, AnimalNeurodegenerative DiseasesVirus Diseases

Identifiers

PMID20561356
PMCPMC2814458
OpenAlexW2160239222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.