ArticleInsect molecular biology2010
Decreased detoxification genes and genome size make the human body louse an efficient model to study xenobiotic metabolism.
Article in Insect molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 106 citations in OpenAlex.
- Functional Annotation and Comparative Analysis of Cytochrome P450 Protein Family Genes in Nine Chironomidae Species.Biology · 2025Article
- Review
- Functional roles of two novel P450 genes in the adaptability ofFrontiers in physiology · 2023Article
- Comparative analysis of detoxification-related gene superfamilies across five hemipteran species.BMC genomics · 2022Article
- Genome-Wide Identification of P450 Genes in ChironomidInsects · 2022Article
- Human pediculosis, a global public health problem.Infectious diseases of poverty · 2022Review
- New chemistries for the control of human head lice, Pediculus humanus capitis: A mini-review.Pesticide biochemistry and physiology · 2022Review
- Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis).Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2021Article
- Article
- Reduced proinsecticide activation by cytochrome P450 confers coumaphos resistance in the major bee parasiteProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Full-length transcriptome analysis ofPeerJ · 2021Article
- Function Analysis of P450 and GST Genes to Imidacloprid inFrontiers in physiology · 2020Article
- Genome-wide survey of cytochrome P450 genes in the salmon louse Lepeophtheirus salmonis (Krøyer, 1837).Parasites & vectors · 2019Article
- Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity.International journal of molecular sciences · 2019Review
- Where Are We With Human Lice? A Review of the Current State of Knowledge.Frontiers in cellular and infection microbiology · 2019Review
- Identification of cytochrome P450 monooxygenase genes and their expression in response to high temperature in the alligatorweed flea beetle Agasicles hygrophila (Coleoptera: Chrysomelidae).Scientific reports · 2018Article
- CYP6AE gene cluster knockout in Helicoverpa armigera reveals role in detoxification of phytochemicals and insecticides.Nature communications · 2018Article
- Genome-wide analysis of ATP-binding cassette (ABC) transporters in the sweetpotato whitefly, Bemisia tabaci.BMC genomics · 2017Article
- Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta.Insect biochemistry and molecular biology · 2016Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
The human body louse, Pediculus humanus humanus, has one of the smallest insect genomes, containing ∼10 775 annotated genes. Annotation of detoxification [cytochrome P450 monooxygenase (P450), glutathione-S-transferase (GST), esterase (Est) and ATP-binding cassette transporter (ABC transporter)] genes revealed that they are dramatically reduced in P. h. humanus compared to other insects except for Apis mellifera. There are 37 P450, 13 GST and 17 Est genes present in P. h. humanus, approximately half the number found in Drosophila melanogaster and Anopheles gambiae. The number of putatively functional ABC transporter genes in P. h. humanus and Ap. mellifera are the same (36) but both have fewer than An. gambiae (44) or Dr. melanogaster (65). The reduction of detoxification genes in P. h. humanus may be a result of this louse's simple life history, in which it does not encounter a wide variety of xenobiotics. Neuronal component genes are highly conserved across different insect species as expected because of their critical function. Although reduced in number, P. h. humanus still retains at least a minimum repertoire of genes known to confer metabolic or toxicokinetic resistance to xenobiotics (eg Cyp3 clade P450s, Delta GSTs, B clade Ests and B/C subfamily ABC transporters), suggestive of its high potential for resistance development.
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Registered trials
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