ArticleMedical mycology2011
Role of NADPH oxidase in host defense against aspergillosis.
Article in Medical mycology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Invasive pulmonary aspergillosis in the ICU: the corticosteroid link.Pneumonia (Nathan Qld.) · 2026Review
- Defective antifungal immunity in patients with COVID-19.Frontiers in immunology · 2022Review
- Inherited CARD9 Deficiency: Invasive Disease Caused by Ascomycete Fungi in Previously Healthy Children and Adults.Journal of clinical immunology · 2018Review
- Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Response.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- First Line of Defense: Innate Cell-Mediated Control of Pulmonary Aspergillosis.Frontiers in microbiology · 2016Review
- The complex roles of NADPH oxidases in fungal infection.Cellular microbiology · 2014Review
- The mycobiota: interactions between commensal fungi and the host immune system.Nature reviews. Immunology · 2014Review
- NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.Infection and immunity · 2014Article
- Myeloperoxidase: a front-line defender against phagocytosed microorganisms.Journal of leukocyte biology · 2013Review
- Regulation of innate immunity by NADPH oxidase.Free radical biology & medicine · 2012Review
- Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The role of reactive oxygen intermediates in experimental coccidioidomycois in mice.BMC microbiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
NADPH oxidase plays a critical role in antimicrobial host defense, as evident in chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal diseases. Invasive aspergillosis and other moulds are the major cause of mortality in CGD. We also learn from CGD patients that NADPH oxidase plays an important role in regulating inflammation; CGD patients are prone to developing inflammatory diseases such as inflammatory bowel disease, obstructive granulomata of the genitourinary tract, and hypersensitivity pneumonitis. Indeed, the NADPH oxidase plays an essential role in calibrating innate and T-cell responses to control the growth of inhaled fungi while protecting against excessive and injurious inflammation. Knowledge gained on the mechanisms by which NADPH oxidase kills fungi and regulates inflammation may lead to new therapeutics for CGD and will have broad relevance to understanding host-pathogen interactions between mammals and ubiquitous moulds to which we are continually exposed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.