ReviewMedical mycology2011
Implications of hypoxic microenvironments during invasive aspergillosis.
Review in Medical mycology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Lactate Levels in a Replanted Limb as an Early Biomarker for Assessing Post-Surgical Evolution: A Case Report.Diagnostics (Basel, Switzerland) · 2025Article
- Convergent evolution in toxin detection and resistance provides evidence for conserved bacterial-fungal interactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics-a narrative review.Critical care (London, England) · 2024Review
- Pathogenicity and virulence ofVirulence · 2023Review
- Novel Insights intoJournal of fungi (Basel, Switzerland) · 2022Review
- Pathogenesis of Respiratory Viral and Fungal Coinfections.Clinical microbiology reviews · 2022Review
- Characterization of theInternational journal of molecular sciences · 2021Article
- Variation of virulence of five Aspergillus fumigatus isolates in four different infection models.PloS one · 2021Article
- Detection of Low Oxygen Microenvironments in a Murine Model of Invasive Pulmonary Aspergillosis Using Pimonidazole.Methods in molecular biology (Clifton, N.J.) · 2021Article
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- RgsA Attenuates the PKA Signaling, Stress Response, and Virulence in the Human Opportunistic PathogenInternational journal of molecular sciences · 2019Article
- Genetic deficiency of NOD2 confers resistance to invasive aspergillosis.Nature communications · 2018Article
- Mitogen activated protein kinases (MAPK) and protein phosphatases are involved inCell surface (Amsterdam, Netherlands) · 2018Article
- Sniffing out the hypoxia volatile metabolic signature of Aspergillus fumigatus.Journal of breath research · 2017Article
- Posaconazole-Loaded Leukocytes as a Novel Treatment Strategy Targeting Invasive Pulmonary Aspergillosis.The Journal of infectious diseases · 2017Article
- Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.Antimicrobial agents and chemotherapy · 2016Article
- The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance.Journal of microbiology (Seoul, Korea) · 2016Review
- Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus.PLoS neglected tropical diseases · 2015Article
- Insights into the cellular responses to hypoxia in filamentous fungi.Current genetics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In order to cause disease, all pathogens must tolerate microenvironmental stresses encountered in vivo during infection. One microenvironmental stress that is known to occur at sites of tissue damage is hypoxia. Yet, the occurrence and impact of hypoxic microenvironments during invasive aspergillosis, caused by the mold Aspergillus fumigatus, are essentially unknown. Here, we briefly review the potential implications of hypoxic microenvironments on the Aspergillus-host interaction. We focus on three areas where hypoxia may play a role in determining the outcome of infection: fungal virulence, host immune responses, and efficacy of current antifungal drug treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.