ReviewJournal of cardiovascular translational research2008
Interactome of a cardiopoietic precursor.
Review in Journal of cardiovascular translational research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Cardiac stem cells: Current knowledge and future prospects.World journal of stem cells · 2022Review
- Natural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines.Circulation. Cardiovascular genetics · 2013Article
- Stem cell systems informatics for advanced clinical biodiagnostics: tracing molecular signatures from bench to bedside.Croatian medical journal · 2013Review
- Decoded calreticulin-deficient embryonic stem cell transcriptome resolves latent cardiophenotype.Stem cells (Dayton, Ohio) · 2010Article
- Cardiogenic induction of pluripotent stem cells streamlined through a conserved SDF-1/VEGF/BMP2 integrated network.PloS one · 2010Article
- Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis.Differentiation; research in biological diversity · 2009Article
- Guided stem cell cardiopoiesis: discovery and translation.Journal of molecular and cellular cardiology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pluripotency is a hallmark feature of embryonic stem cells, but concomitantly expressed transcripts confound resolution of specific developmental signaling axes. Ratification of a molecular fingerprint critical to cardiogenesis mandated investigation of gene expression in stem-cell-derived cardiac precursors undergoing guided differentiation to define genomic networks responsible for cardiogenic progression. Upregulated transcripts organized into a discrete network with enhanced themes of "cardiovascular development" and "cellular movement", while downregulated transcripts demonstrated significant overrepresentation of "oncogenesis" and "gene expression". Ontological characterization of molecular functions revealed robust enrichment of binding factor classifications that bolstered upregulated themes of cardiovascular development and cellular movement, and significant nonstochastic overrepresentation of gene metabolism that drove oncogenic and gene expression network themes in downregulated transcripts. Collectively, these global adjustments engaged a systems biology repertoire switch towards functional specification. Thus, resolution of a precursor pedigree reveals coordinated themes that facilitate a nascent interactome which guides embryonic stem cell cardiopoiesis.
Indexed as
Identifiers
20559906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.