ArticleInternational journal of hematology2010
Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells.
Article in International journal of hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Reawakening Differentiation Therapy in Acute Myeloid Leukemia: A Comprehensive Review of ATRA-Based Combination Strategies.Current oncology (Toronto, Ont.) · 2026Review
- Enhanced Killing of Colon Cancer Cells by Mesoporous Silica Nanoparticles Loaded with Ellagic Acid.Nanomaterials (Basel, Switzerland) · 2025Article
- Red osier dogwood and its use in animal nutrition: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential.International journal of molecular sciences · 2021Review
- Ellagic Acid Containing Nanostructured Lipid Carriers for Topical Application: A Preliminary Study.Molecules (Basel, Switzerland) · 2020Article
- Traditional Tibetan Medicine in Cancer Therapy by Targeting Apoptosis Pathways.Frontiers in pharmacology · 2020Review
- KIF20A, highly expressed in immature hematopoietic cells, supports the growth of HL60 cell line.International journal of hematology · 2018Article
- Cell type-dependent effects of ellagic acid on cellular metabolism.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018Article
- Ellagic acid induces HeLa cell apoptosis via regulating signal transducer and activator of transcription 3 signaling.Experimental and therapeutic medicine · 2018Article
- Towards a better understanding of the therapeutic applications and corresponding mechanisms of action of honey.Environmental science and pollution research international · 2017Review
- Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo.International journal of oncology · 2017Article
- Leaf and Root Extracts fromFrontiers in pharmacology · 2017Article
- The Effects of Ellagic Acid upon Brain Cells: A Mechanistic View and Future Directions.Neurochemical research · 2016Review
- Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy.Oxidative medicine and cellular longevity · 2015Review
- EZH2, an epigenetic driver of prostate cancer.Protein & cell · 2013Review
- Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines.Food science & nutrition · 2013Article
- Ellagic Acid Reduces Adipogenesis through Inhibition of Differentiation-Prevention of the Induction of Rb Phosphorylation in 3T3-L1 Adipocytes.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- A review of molecular mechanisms of the anti-leukemic effects of phenolic compounds in honey.International journal of molecular sciences · 2012Review
- Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system.Surgical neurology international · 2012Article
- Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies.Advances in hematology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All-trans retinoic acid (ATRA) is a standard drug used for differentiation therapy in acute promyelocytic leukemia. To potentiate this therapy, we examined the effect of ellagic acid (EA), a natural polyphenolic compound with antiproliferative and antioxidant properties, on the growth and differentiation of HL-60 acute myeloid leukemia cells. EA was found to induce apoptosis, which was blocked by pan-caspase inhibitor, Z-VAD-FMK. EA activated the caspase-3 pathway and enhanced the expressions of myeloid differentiation markers (CD11b, MRP-14 protein, granulocytic morphology) induced by ATRA treatment. These results indicate that EA is a potent apoptosis inducer and also effectively potentiates ATRA-induced myeloid differentiation of HL-60 cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.