ArticlePharmaceutical research2010
Targeted polymeric micelle system for delivery of combretastatin A4 to tumor vasculature in vitro.
Article in Pharmaceutical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery.The journal of physical chemistry. B · 2023Review
- Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides.Molecules (Basel, Switzerland) · 2021Review
- Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells.Scientific reports · 2021Article
- Combretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications.Molecules (Basel, Switzerland) · 2020Review
- Proinflammatory macrophage-derived microvesicles exhibit tumor tropism dependent on CCL2/CCR2 signaling axis and promote drug deliveryTheranostics · 2020Article
- Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives.Molecules (Basel, Switzerland) · 2019Review
- Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinoma.Journal of Cancer · 2019Article
- Curcumin Delivery by Poly(Lactide)-Based Co-Polymeric Micelles: An In Vitro Anticancer Study.Pharmaceutical research · 2016Article
- Bibliometric analysis of nanotechnology applied in oncology from 2002 to 2011.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Review
- Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy.International journal of nanomedicine · 2011Article
- Recent advances in PEG-PLA block copolymer nanoparticles.International journal of nanomedicine · 2010Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo develop an efficient tumor vasculature-targeted polymeric micelle delivery system for combretastatin A4 (CA4), a novel antivascular agent.
methodsCA4-loaded micelles were prepared from poly (ethylene glycol)-b-poly (d, l-lactide) copolymers. RGD peptides that target integrins alphavbeta3 and alphavbeta5, markers of angiogenic endothelial cells, were coupled to the surface of micelles. The micelles were characterized in terms of particle size, morphology, drug loading, and drug release. Cellular uptake of micelles was evaluated by fluorometric determination and confocal microscopy. Anti-proliferation of targeted micelles was also evaluated by SRB method.
resultsThe mean diameters of CA4-loaded targeted micelles were 25.9 +/- 1.3 nm and spherical in shape. Approximately 4 mg/mL of micellar CA4 loading was obtained with an entrapment efficiency of 97.2 +/- 1.4%. In vitro release studies revealed that targeted micelles release CA4 in a sustained-release manner within 48 h. In vitro cellular uptake studies demonstrated that targeted micelles significantly facilitated the intracellular delivery of the encapsulated agents via integrin-mediated endocytosis. Anti-proliferation studies showed that targeted micelles containing CA4 present superior efficacy over nontargeted micelles.
conclusionThese results suggested that RGD conjugated PEG-PLA micelles loading CA4 have potential as a new formulation for targeting angiogenic tumor vasculature.
Indexed as
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20559700What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.