ArticlePLoS neglected tropical diseases2010
Spatial and genetic epidemiology of hookworm in a rural community in Uganda.
Article in PLoS neglected tropical diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Epidemiological surveys of, and research on, soil-transmitted helminths in Southeast Asia: a systematic review.Parasites & vectors · 2016Pooled it
- Cost and cost-effectiveness of soil-transmitted helminth treatment programmes: systematic review and research needs.Parasites & vectors · 2015Pooled it
- Sensitivity of diagnostic tests for human soil-transmitted helminth infections: a meta-analysis in the absence of a true gold standard.International journal for parasitology · 2014Pooled it
- Association between footwear use and neglected tropical diseases: a systematic review and meta-analysis.PLoS neglected tropical diseases · 2014Pooled it
- Epidemiology of soil transmitted helminths and risk analysis of hookworm infections in the community: Results from the DeWorm3 Trial in southern India.PLoS neglected tropical diseases · 2021Trial
- Community-level epidemiology of soil-transmitted helminths in the context of school-based deworming: Baseline results of a cluster randomised trial on the coast of Kenya.PLoS neglected tropical diseases · 2019Trial
- The impact of a school-based hygiene, water quality and sanitation intervention on soil-transmitted helminth reinfection: a cluster-randomized trial.The American journal of tropical medicine and hygiene · 2013Trial
- Spatial modeling of soil-transmitted helminthiases in Colombia under climate change scenariosBiomedica : revista del Instituto Nacional de Salud · 2025Article
- Achieving elimination of soil-transmitted helminthiasis as a public health problem in Mali.BMJ global health · 2025Article
- Spatial distribution patterns and risk factors of hookworm disease in China: A study based on successive national surveillance.PLoS neglected tropical diseases · 2025Article
- The Relationship Between Soil-Transmitted Helminth Infections and Environmental Factors in Puerto Iguazú, Argentina: Cross-Sectional Study.JMIR public health and surveillance · 2023Article
- Prevalence of Intestinal Parasitic Infections, Genotypes, and Drug Susceptibility ofTropical medicine and infectious disease · 2023Article
- Soil-transmitted helminthiasis in mainland China from 2016 to 2020: a population-based study.The Lancet regional health. Western Pacific · 2023Article
- Using Routinely Collected Health Records to Identify the Fine-Resolution Spatial Patterns of Soil-Transmitted Helminth Infections in Rwanda.Tropical medicine and infectious disease · 2022Article
- Risk of acquiringEpidemiology and infection · 2022Article
- Appropriateness of the current parasitological control target for hookworm morbidity: A statistical analysis of individual-level data.PLoS neglected tropical diseases · 2022Article
- Survey Design to Monitor Drug Efficacy for the Control of Soil-Transmitted Helminthiasis and Schistosomiasis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Effect of Lymphatic Filariasis and Hookworm Infection on Pregnancy Course and Outcome in Women Living in the Democratic Republic of the Congo.The American journal of tropical medicine and hygiene · 2021Article
- Prevalence and Correlation Analysis of Soil-Transmitted Helminths Infections and Treatment Coverage for Preschool and School Aged Children in Kenya: Secondary Analysis of the National School Based Deworming Program Data.Frontiers in public health · 2021Article
- Baseline patterns of infection in regions of Benin, Malawi and India seeking to interrupt transmission of soil transmitted helminths (STH) in the DeWorm3 trial.PLoS neglected tropical diseases · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
There are remarkably few contemporary, population-based studies of intestinal nematode infection for sub-Saharan Africa. This paper presents a comprehensive epidemiological analysis of hookworm infection intensity in a rural Ugandan community. Demographic, kinship, socioeconomic and environmental data were collected for 1,803 individuals aged six months to 85 years in 341 households in a cross-sectional community survey. Hookworm infection was assessed by faecal egg count. Spatial variation in the intensity of infection was assessed using a Bayesian negative binomial spatial regression model and the proportion of variation explained by host additive genetics (heritability) and common domestic environment was estimated using genetic variance component analysis. Overall, the prevalence of hookworm was 39.3%, with the majority of infections (87.7%) of light intensity (<or=1000 eggs per gram faeces). Intensity was higher among older individuals and was associated with treatment history with anthelmintics, walking barefoot outside the home, living in a household with a mud floor and education level of the household head. Infection intensity also exhibited significant household and spatial clustering: the range of spatial correlation was estimated to be 82 m and was reduced by a half over a distance of 19 m. Heritability of hookworm egg count was 11.2%, whilst the percentage of variance explained by unidentified domestic effects was 17.8%. In conclusion, we suggest that host genetic relatedness is not a major determinant of infection intensity in this community, with exposure-related factors playing a greater role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.