ArticlePloS one2010
Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Occupational exposure to video display terminals: a systematic review of ocular and visual health effects and associated risk factors.Journal of occupational health · 2026Pooled it
- Prevalence of dry eye disease in visual display terminal workers: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- Full-spectrum LED screen-bar lighting as an adjunct to artificial tears in visual display terminal-related dry eye: a randomized study.International ophthalmology · 2026Trial
- Effect of warming eyelids on tear film stability and quality of life in visual display terminal users: a randomized controlled trial.Scientific reports · 2020Trial
- The Effects of Chewing Gum in Preventing Eyestrain.BioMed research international · 2020Trial
- Trial
- The increase of aqueous tear volume by diquafosol sodium in dry-eye patients with Sjögren's syndrome: a pilot study.Eye (London, England) · 2016Trial
- Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye.Translational vision science & technology · 2025Article
- Tear Film Dynamics in Visual Display Terminal Users: A Review of Impact on Goblet Cells, Lacrimal and Meibomian Gland Function.Seminars in ophthalmology · 2025Review
- Effectiveness of an Acupuncture Steam-Warming Eye Mask on Dry Eye Disease in Visual Display Terminal Users: A Prospective Randomized Controlled Trial.Diseases (Basel, Switzerland) · 2024Article
- Digital Eye Strain: Updated Perspectives.Clinical optometry · 2024Review
- Dry Eyes among Visual Display Terminal Users Visiting the Outpatient Department of Ophthalmology of a Tertiary Care Centre.JNMA; journal of the Nepal Medical Association · 2023Article
- Autonomic Nerve Activity Features According to Dry Eye Type.Investigative ophthalmology & visual science · 2023Article
- A study on correlation of computer vision syndrome and dry eye disease and knowledge regarding its associated factors amongst health professionals.Indian journal of ophthalmology · 2023Article
- Heterochronic Parabiosis Causes Dacryoadenitis in Young Lacrimal Glands.International journal of molecular sciences · 2023Article
- Assessment of risk factors on eye dryness in young adults using visual display device in both contact lens wearers and non-wearers.International ophthalmology · 2023Article
- Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease.Acta ophthalmologica · 2022Review
- Prevalence of dry eye disease among Chinese high school students during the COVID-19 outbreak.BMC ophthalmology · 2022Article
- Current approaches for the regeneration and reconstruction of ocular surface in dry eye.Frontiers in medicine · 2022Review
- Inflammation and dry eye disease-where are we?International journal of ophthalmology · 2022Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDry eye has shown a marked increase due to visual display terminal (VDT) use. It remains unclear whether reduced blinking while focusing can have a direct deleterious impact on the lacrimal gland function. To address this issue that potentially affects the life quality, we conducted a large-scale epidemiological study of VDT users and an animal study. METHODOLOGY/PRINCIPAL
findingsCross sectional survey carried out in Japan. A total of 1025 office workers who use VDT were enrolled. The association between VDT work duration and changes in tear film status, precorneal tear stability, lipid layer status and tear secretion were analyzed. For the animal model study, the rat VDT user model, placing rats onto a balance swing in combination with exposure to an evaporative environment was used to analyze lacrimal gland function. There was no positive relationship between VDT working duration and change in tear film stability and lipid layer status. The odds ratio for decrease in Schirmer score, index of tear secretion, were significantly increased with VDT working year (P = 0.012) and time (P = 0.005). The rat VDT user model, showed chronic reduction of tear secretion and was accompanied by an impairment of the lacrimal gland function and morphology. This dysfunction was recovered when rats were moved to resting conditions without the swing. CONCLUSIONS/SIGNIFICANCE: These data suggest that lacrimal gland hypofunction is associated with VDT use and may be a critical mechanism for VDT-associated dry eye. We believe this to be the first mechanistic link to the pathogenesis of dry eye in office workers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.