ArticleJournal of physics. Condensed matter : an Institute of Physics journal2010
Actin disassembly 'clock' and membrane tension determine cell shape and turning: a mathematical model.
Article in Journal of physics. Condensed matter : an Institute of Physics journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions.Biophysical journal · 2023Article
- Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration.Cell systems · 2020Article
- A free-boundary model of a motile cell explains turning behavior.PLoS computational biology · 2017Article
- Crawling and turning in a minimal reaction-diffusion cell motility model: Coupling cell shape and biochemistry.Physical review. E · 2017Article
- Periodic migration in a physical model of cells on micropatterns.Physical review letters · 2013Article
- Actin disassembly clock determines shape and speed of lamellipodial fragments.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells.Cellular and molecular bioengineering · 2011Article
- Cytoskeletal actin networks in motile cells are critically self-organized systems synchronized by mechanical interactions.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Theoretical model for cellular shapes driven by protrusive and adhesive forces.PLoS computational biology · 2011Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Motile cells regulate their shape and movements largely by remodeling the actin cytoskeleton. Principles of this regulation are becoming clear for simple-shaped steadily crawling cells, such as fish keratocytes. In particular, the shape of the leading edge and sides of the lamellipodium-cell motile appendage-is determined by graded actin distribution at the cell boundary, so that the denser actin network at the front grows, while sparser actin filaments at the sides are stalled by membrane tension. Shaping of the cell rear is less understood. Here we theoretically examine the hypothesis that the cell rear is shaped by the disassembly clock: the front-to-rear lamellipodial width is defined by the time needed for the actin-adhesion network to disassemble to the point at which the membrane tension can crush this network. We demonstrate that the theory predicts the observed cell shapes. Furthermore, turning of the cells can be explained by biases in the actin distribution. We discuss experimental implications of this hypothesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.