ArticleEMBO reports2010
Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.
Article in EMBO reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome-Linked p63 Mutations Disrupt Keratinocyte Proliferation and Survival Through Oxidative Stress and Impaired Slc7a11 Expression.International journal of molecular sciences · 2025Article
- A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans.The EMBO journal · 2023Article
- The dual role of p63 in cancer.Frontiers in oncology · 2023Review
- Structural diversity of p63 and p73 isoforms.Cell death and differentiation · 2022Review
- Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo.Experimental animals · 2021Article
- Atypical cyclins: the extended family portrait.Cellular and molecular life sciences : CMLS · 2020Review
- Loss-of-function mutations in theEndocrine-related cancer · 2017Article
- The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System.International journal of molecular sciences · 2016Review
- Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3.Oncogene · 2015Article
- Cables1 complex couples survival signaling to the cell death machinery.Cancer research · 2015Article
- Regulation of p63 protein stability via ubiquitin-proteasome pathway.BioMed research international · 2014Review
- Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance.Cell cycle (Georgetown, Tex.) · 2012Article
- The p53 circuit board.Biochimica et biophysica acta · 2012Review
- Article
- The role of p63 in cancer, stem cells and cancer stem cells.Cellular & molecular biology letters · 2011Review
- cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish.Molecular reproduction and development · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The p63 gene product regulates epithelial morphogenesis and female germline integrity. In this study, we show that cyclin-dependent kinase 5 and Abl enzyme substrate 1 (Cables1) interacts with the trans-activating (TA) p63alpha isoform to protect it from proteasomal degradation. Using the female germline of Cables1-null mice as an in vivo model, we demonstrate further that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress. This in turn enhances the survival of these cells after ionizing radiation exposure. Thus, Cables1 modulates p63 protein stability and function during genotoxic stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.