Evidence map›Paper›PMID 20558996›Full record

ArticleHuman heredity2010

Pilot study on schizophrenia in Sardinia.

Jurg Ott, Fabio Macciardi, Yuanyuan Shen, Mauro G Carta, Andrea Murru, Riccardo Triunfo, Renato Robledo, Antoniettina Rinaldi, Licinio Contu, Marcello Siniscalco

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human heredity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Schizophrenia: from epidemiology to rehabilitation.Clinical practice and epidemiology in mental health : CP & EMH · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jurg OttBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Fabio Macciardi
Yuanyuan Shen
Mauro G Carta
Andrea Murru
Riccardo Triunfo
Renato Robledo
Antoniettina Rinaldi
Licinio Contu
Marcello Siniscalco

Funding

Genetic Modifiers for 22q 11.2 Deletion SyndromeR01HL084410 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MORROW, BERNICE E · 2007 to 2010
$3.3M
Genetic Associations with Alzheimer-free SurvivalR01AG026916 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRAMER, PATRICIA L · 2005 to 2008
$1.8M
NHLBI NIH HHS HL084410NHLBI NIH HHS R01 HL084410NIA NIH HHS AG026916NIA NIH HHS R01 AG026916
6 · The paper itself

Abstract

objectiveBased on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease.

methodsStandard association tests were employed, followed by newer multilocus association methods (genotype patterns).

resultsIndividually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively.

conclusionsThese findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect.

Indexed as

Genetic Predisposition to DiseaseAdultAllelesCase-Control StudiesFemaleGene FrequencyGenome-Wide Association StudyHumansItalyMaleMiddle AgedPilot ProjectsPolymorphism, Single NucleotideSchizophrenia

Identifiers

PMID20558996
PMCPMC7077084

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.