ArticleArteriosclerosis, thrombosis, and vascular biology2010
Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Reperfusion‑targeted AnxA1sp restores mitochondrial resilience through mitoKATP activation to limit diabetic myocardial ischemia‑reperfusion injury.Journal of translational medicine · 2026Article
- Targeting Neutrophils for Promoting the Resolution of Inflammation.Frontiers in immunology · 2022Review
- From NSAIDs to Glucocorticoids and Beyond.Cells · 2021Review
- In Patients With Obesity, the Number of Adipose Tissue Mast Cells Is Significantly Lower in Subjects With Type 2 Diabetes.Frontiers in immunology · 2021Article
- Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation.American journal of physiology. Cell physiology · 2020Article
- Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites.NPJ science of food · 2020Article
- Cromolyn, a New Hope for Limited Treatment of Neutrophilic Asthma: a Phase II Randomized Clinical Trial.Tanaffos · 2019Article
- Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions.Frontiers in pharmacology · 2019Article
- Discovering Pediatric Asthma Phenotypes on the Basis of Response to Controller Medication Using Machine Learning.Annals of the American Thoracic Society · 2018Article
- The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1.The Journal of biological chemistry · 2017Article
- Mast cells mediate early neutrophil recruitment and exhibit anti-inflammatory properties via the formyl peptide receptor 2/lipoxin ABritish journal of pharmacology · 2017Article
- The Anti-allergic Cromones: Past, Present, and Future.Frontiers in pharmacology · 2017Review
- Annexin A1: shifting the balance towards resolution and repair.Biological chemistry · 2016Review
- Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.Disease models & mechanisms · 2016Article
- The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.International immunopharmacology · 2016Article
- Annexin A1 mediates hydrogen sulfide properties in the control of inflammation.The Journal of pharmacology and experimental therapeutics · 2014Article
- TWEAK enhances E-selectin and ICAM-1 expression, and may contribute to the development of cutaneous vasculitis.PloS one · 2013Article
- Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1.PloS one · 2013Article
- The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis.Annals of the rheumatic diseases · 2012Article
- Prednisolone exerts exquisite inhibitory properties on platelet functions.Biochemical pharmacology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether the inhibitory action of the antiallergic cromone "mast cell stabilizing" drugs on polymorphonuclear leukocyte (PMN) trafficking is mediated through an annexin-A1 (Anx-A1) dependent mechanism. METHODS AND
resultsIntravital microscopy was used to monitor the actions of cromones in the inflamed microcirculation. Reperfusion injury provoked a dramatic increase in adherent and emigrated leukocytes in the mesenteric vascular bed, associated with augmented tissue levels of myeloperoxidase. Nedocromil, 2 to 20 mg/kg, significantly (P<0.05) inhibited cell adhesion and emigration, as well as myeloperoxidase release, in wild-type but not Anx-A1(-/-) mice. Short pretreatment of human PMNs with nedocromil, 10 nmol/L, inhibited cell adhesion (P<0.05) in the flow chamber assay, and this effect was reversed by specific anti-AnxA1 or a combination of antiformyl peptide receptors 1 and 2, but not irrelevant control, antibodies. Western blotting experiments revealed that cromones stimulate protein kinase C-dependent phosphorylation and release Anx-A1 in human PMNs.
conclusionsWe propose a novel mechanism to explain the antiinflammatory actions of cromones on PMN trafficking, an effect that has long puzzled investigators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.