ArticleProceedings of the National Academy of Sciences of the United States of America2010
Carbon dioxide fixation as a central redox cofactor recycling mechanism in bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 330 citations in OpenAlex.
- Atomic elementary flux modes explain the steady state flow of metabolites in large-scale flux networks.Cell reports methods · 2026Article
- Machine learning reveals proteome-encoded growth determinants underlying metabolic versatility ofmSystems · 2026Article
- Reciprocal cross-feeding between bacteria can limit the emergence of metabolic dependencies.Applied and environmental microbiology · 2026Article
- Article
- Nitrogenase regulation inbioRxiv : the preprint server for biology · 2026Article
- Purple phototrophic bacteria release crotonate as a metabolic overflow pathway.Communications biology · 2026Article
- Article
- Metagenomic sequencing and binning reveal carbon cycling microorganisms and gene functions in park environments.BMC microbiology · 2026Article
- Integrating resource utilization and bioregenerative life support systems for sustainable space exploration.Frontiers in microbiology · 2026Review
- Sulfur Cycling and Life Strategies in Successional Biocrusts Link to Biomass Carbon in Dryland Ecosystems.Microorganisms · 2025Article
- Primary production by the purple nonsulfur bacteriumApplied and environmental microbiology · 2025Article
- Non-Respiratory Extracellular Electron Transfer Competes with Nitrogenase for Electrons in Rhodopseudomonas Palustris.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Redox poise in R. rubrum phototrophic growth drives large-scale changes in macromolecular pathways.PLoS computational biology · 2025Article
- Evaluation of nitrogen fixation in the marine purple photosynthetic bacterium Rhodovulum sulfidophilum under autotrophic and heterotrophic conditions.Scientific reports · 2025Article
- PApplied and environmental microbiology · 2025Article
- AApplied and environmental microbiology · 2025Article
- Cryptic iron cycling influenced by organic carbon availability in a seasonally stratified lake.FEMS microbiology ecology · 2025Article
- Genomic highlights of the phylogenetically unique halophilic purple nonsulfur bacterium, Rhodothalassium salexigens.Extremophiles : life under extreme conditions · 2025Article
- The proteome is a terminal electron acceptor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microbial cross-feeding stabilized by segregation of a dependent mutant from its independent ancestor.The ISME journal · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Calvin-Benson-Bassham cycle (Calvin cycle) catalyzes virtually all primary productivity on Earth and is the major sink for atmospheric CO(2). A less appreciated function of CO(2) fixation is as an electron-accepting process. It is known that anoxygenic phototrophic bacteria require the Calvin cycle to accept electrons when growing with light as their sole energy source and organic substrates as their sole carbon source. However, it was unclear why and to what extent CO(2) fixation is required when the organic substrates are more oxidized than biomass. To address these questions we measured metabolic fluxes in the photosynthetic bacterium Rhodopseudomonas palustris grown with (13)C-labeled acetate. R. palustris metabolized 22% of acetate provided to CO(2) and then fixed 68% of this CO(2) into cell material using the Calvin cycle. This Calvin cycle flux enabled R. palustris to reoxidize nearly half of the reduced cofactors generated during conversion of acetate to biomass, revealing that CO(2) fixation plays a major role in cofactor recycling. When H(2) production via nitrogenase was used as an alternative cofactor recycling mechanism, a similar amount of CO(2) was released from acetate, but only 12% of it was reassimilated by the Calvin cycle. These results underscore that N(2) fixation and CO(2) fixation have electron-accepting roles separate from their better-known roles in ammonia production and biomass generation. Some nonphotosynthetic heterotrophic bacteria have Calvin cycle genes, and their potential to use CO(2) fixation to recycle reduced cofactors deserves closer scrutiny.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.