ArticleThe Journal of biological chemistry2010
Lamellar bodies form solid three-dimensional films at the respiratory air-liquid interface.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The pristine unused pulmonary surfactant isolated from human amniotic fluid forms highly condensed interfacial films.Physiological reports · 2025Article
- Surfactant protein SP-B: one ring to rule the molecular and biophysical mechanisms of the pulmonary surfactant system.Biophysical reviews · 2025Review
- Acidic Enough for a Healthy Breath.American journal of respiratory cell and molecular biology · 2024Article
- Novel opportunities from bioimaging to understand the trafficking and maturation of intracellular pulmonary surfactant and its role in lung diseases.Frontiers in immunology · 2023Review
- Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Review
- Spectral phasor analysis of LAURDAN fluorescence in live A549 lung cells to study the hydration and time evolution of intracellular lamellar body-like structures.Biochimica et biophysica acta · 2016Article
- Tensiometric and Phase Domain Behavior of Lung Surfactant on Mucus-like Viscoelastic Hydrogels.ACS applied materials & interfaces · 2016Article
- Pneumocytes Assemble Lung Surfactant as Highly Packed/Dehydrated States with Optimal Surface Activity.Biophysical journal · 2015Article
- Article
- Interfacial stress affects rat alveolar type II cell signaling and gene expression.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant.Biochimica et biophysica acta · 2012Article
- Interfacial sensing by alveolar type II cells: a new concept in lung physiology?American journal of physiology. Cell physiology · 2011Article
- Meconium impairs pulmonary surfactant by a combined action of cholesterol and bile acids.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Pulmonary surfactant is essential for lung function. It is assembled, stored and secreted as particulate entities (lamellar body-like particles; LBPs). LBPs disintegrate when they contact an air-liquid interface, leading to an instantaneous spreading of material and a decline in surface tension. Here, we demonstrate that the film formed by the adsorbed material spontaneously segregate into distinct ordered and disordered lipid phase regions under unprecedented near-physiological conditions and, unlike natural surfactant purified from bronchoalveolar lavages, dynamically reorganized into highly viscous multilayer domains with complex three-dimensional topographies. Multilayer domains, in coexistence with liquid phases, showed a progressive stiffening and finally solidification, probably driven by a self-driven disassembly of LBPs from a sub-surface compartment. We conclude that surface film formation from LBPs is a highly dynamic and complex process, leading to a more elaborated scenario than that observed and predicted by models using reconstituted, lavaged, or fractionated preparations.
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