ArticleAmerican journal of respiratory and critical care medicine2010
Toward an integrated research agenda for critical illness in aging.
Article in American journal of respiratory and critical care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Enhancing healthcare AI stability with edge computing and machine learning for extubation prediction.Scientific reports · 2025Article
- Inflammation and aging-related disease: A transdisciplinary inflammaging framework.GeroScience · 2025Review
- MEG8 as an antagonistic pleiotropic mechanism in breast cancer.Cell death discovery · 2024Article
- Crossing Age Boundaries: The Unifying Potential of Presepsin in Sepsis Diagnosis Across Diverse Age Groups.Journal of clinical medicine · 2024Review
- Effect of metformin on sepsis-associated acute lung injury and gut microbiota in aged rats with sepsis.Frontiers in cellular and infection microbiology · 2023Article
- Article
- Increasing Vulnerability in Older Adults With Critical Illness: Implications for Clinical Care and Research.Chest · 2022Article
- Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Early intestinal microbiota changes in aged and adult mice with sepsis.Frontiers in cellular and infection microbiology · 2022Article
- Article
- Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness.Critical care (London, England) · 2020Observational
- Recall of pain and discomfort during oral procedures experienced by intubated critically ill patients in the intensive care unit: A qualitative elicitation study.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.Journal of the American Geriatrics Society · 2020Article
- Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response.Intensive care medicine experimental · 2019Article
- Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints.Shock (Augusta, Ga.) · 2019Review
- Caring for the critically ill patients over 80: a narrative review.Annals of intensive care · 2018Review
- A multimodal rehabilitation program for patients with ICU acquired weakness improves ventilator weaning and discharge home.Journal of critical care · 2018Article
- Article
- Autophagy and mitochondrial biogenesis impairment contribute to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- The relationship between executive dysfunction, depression, and mental health-related quality of life in survivors of critical illness: Results from the BRAIN-ICU investigation.Journal of critical care · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Aging brings an increased predisposition to critical illness. Patients older than 65 years of age account for approximately half of all intensive care unit (ICU) admissions in the United States, a proportion that is expected to increase considerably with the aging of the population. Emerging research suggests that elderly survivors of intensive care suffer significant long-term sequelae, including accelerated age-related functional decline. Existing evidence-based interventions are frequently underused and their efficacy untested in older subjects. Improving ICU outcomes in the elderly will require not only better methods for translating sound science into improved ICU practice but also an enhanced understanding of the underlying molecular, physiological, and pathophysiological interactions of critical illness with the aging process itself. Yet, significant barriers to research for critical illness in aging exist. We review the state of knowledge and identify gaps in knowledge, research opportunities, and barriers to research, with the goal of promoting an integrated research agenda for critical illness in aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.