ArticleMolecular biology and evolution2010
Evolution of the sweet taste receptor gene Tas1r2 in bats.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 94 citations in OpenAlex.
- On the Origin and Evolution of Sweet Taste Mediated by Tas1r2-Tas1r3 in Vertebrates.Integrative zoology · 2026Article
- Emerging technologies for advancing molecular and cellular research in bats.Zoological research · 2026Review
- Taste receptors and their ecological niches: cats, dogs, and other vertebrates.Chemical senses · 2025Review
- Pervasive loss of regulated necrotic cell death genes in elephants, hyraxes, and sea cows (bioRxiv : the preprint server for biology · 2024Article
- Eyeless cave-dwellingScience advances · 2023Article
- Rubbing Salt in the Wound: Molecular Evolutionary Analysis of Pain-Related Genes Reveals the Pain Adaptation of Cetaceans in Seawater.Animals : an open access journal from MDPI · 2022Article
- Quantitative Insights into the Contribution of Nematocysts to the Adaptive Success of Cnidarians Based on Proteomic Analysis.Biology · 2022Article
- Pharmacology of TAS1R2/TAS1R3 Receptors and Sweet Taste.Handbook of experimental pharmacology · 2022Article
- Taste receptors affect male reproduction by influencing steroid synthesis.Frontiers in cell and developmental biology · 2022Review
- Evolutionary insights into umami, sweet, and bitter taste receptors in amphibians.Ecology and evolution · 2021Article
- Bitter taste receptors of the common vampire bat are functional and show conserved responses to metal ionsProceedings. Biological sciences · 2021Article
- Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.Journal of molecular neuroscience : MN · 2021Review
- Loss of sweet taste despite the conservation of sweet receptor genes in insectivorous bats.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- New Insights on the Evolution of the Sweet Taste Receptor of Primates Adapted to Harsh Environments.Animals : an open access journal from MDPI · 2020Article
- Comparative genomic analyses illuminate the distinct evolution of megabats within Chiroptera.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats.GigaScience · 2020Article
- Expansion of sweet taste receptor genes in grass carp (Ctenopharyngodon idellus) coincided with vegetarian adaptation.BMC evolutionary biology · 2020Article
- Trehalase Gene as a Molecular Signature of Dietary Diversification in Mammals.Molecular biology and evolution · 2019Article
- Article
- Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats.Molecular ecology · 2018Article
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taste perception is an important component of an animal's fitness. The identification of vertebrate taste receptor genes in the last decade has enabled molecular genetic studies of the evolution of taste perception in the context of the ecology and dietary preferences of organisms. Although such analyses have been conducted in a number of species for bitter taste receptors, a similar analysis of sweet taste receptors is lacking. Here, we survey the sole sweet taste-specific receptor gene Tas1r2 in 42 bat species that represent all major lineages of the order Chiroptera, one of the most diverse groups of mammals in terms of diet. We found that Tas1r2 is under strong purifying selection in the majority of the bats studied, with no significant difference in the strength of the selection between insect eaters and fruit eaters. However, Tas1r2 is a pseudogene in all three vampire bat species and the functional relaxation likely started in their common ancestor, probably due to the exclusive feeding of vampire bats on blood and their reliance on infrared sensors rather than taste perception to locate blood sources. Our survey of available genome sequences, together with previous reports, revealed additional losses of Tas1r2 in horse, cat, chicken, zebra finch, and western clawed frog, indicating that sweet perception is not as conserved as previously thought. Nonetheless, we found no common dietary pattern among the Tas1r2-lacking vertebrates, suggesting different causes for the losses of Tas1r2 in different species. The complexity of the ecological factors that impact the evolution of Tas1r2 calls for a better understanding of the physiological roles of sweet perception in different species.
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