ArticleJournal of medical microbiology2010
Characterization of lethal inhalational infection with Francisella tularensis in the common marmoset (Callithrix jacchus).
Article in Journal of medical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Inhaled liposomal ciprofloxacin protects against lethal tularemia in the common marmoset.Antimicrobial agents and chemotherapy · 2026Article
- Immunological changes associated with the treatment of pneumonic tularaemia in marmosets.Frontiers in cellular and infection microbiology · 2026Article
- Development, Strategies, and Challenges for Tularemia Vaccine.Current microbiology · 2024Review
- Marmosets as models of infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- Article
- Stochastic dynamics of Francisella tularensis infection and replication.PLoS computational biology · 2020Article
- Adaptive Immunity toFrontiers in cellular and infection microbiology · 2018Review
- The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4.The American journal of pathology · 2017Article
- Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus).International journal of experimental pathology · 2014Article
- Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primates.PLoS pathogens · 2014Article
- Exploring the innate immunological response of an alternative nonhuman primate model of infectious disease; the common marmoset.Journal of immunology research · 2014Article
- Review
- Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus).Infection and immunity · 2013Article
- Article
- Article
- Septic tularemia in 2 cottontop tamarins(Sanguinus oedipus).Comparative medicine · 2012Article
- Development of an acute model of inhalational melioidosis in the common marmoset (Callithrix jacchus).International journal of experimental pathology · 2011Article
- Immunity to Francisella.Frontiers in microbiology · 2011Article
- The francisella tularensis proteome and its recognition by antibodies.Frontiers in microbiology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The intracellular Gram-negative pathogen Francisella tularensis is the causative agent of tularaemia and is prevalent in many countries in the northern hemisphere. To determine whether the common marmoset (Callithrix jacchus) would be a suitable non-human primate model of inhalational tularaemia, a pathophysiology study was undertaken. Ten animals were challenged with approximately 10(2) c.f.u. F. tularensis strain SCHU S4 (F. tularensis subsp. tularensis). To look for trends in the infection, pairs of animals were sacrificed at 24 h intervals between 0 and 96 h post-challenge and blood and organs were assessed for bacteriology, pathology and haematological and immunological parameters. The first indication of infection was a raised core temperature at 3 days post-challenge. This coincided with a number of other factors: a rapid increase in the number of bacteria isolated from all organs, more pronounced gross pathology and histopathology, and an increase in the immunological response. As the disease progressed, higher bacterial and cytokine levels were detected. More extensive pathology was observed, with multifocal lesions seen in the lungs, liver and spleen. Disease progression in the common marmoset appears to be consistent with human clinical and pathological features of tularaemia, indicating that this may be a suitable animal model for the investigation of novel medical interventions such as vaccines or therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.