ReviewExperimental gerontology2010
Immune senescence in aged nonhuman primates.
Review in Experimental gerontology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Aging induces severe SIV infection accompanied by an increase in follicular CD8+ T cells with overactive STAT3 signaling.Cellular & molecular immunology · 2022Article
- Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques.Journal of virology · 2022Article
- Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques.Cell reports · 2022Article
- Improving rigor and reproducibility in nonhuman primate research.American journal of primatology · 2021Review
- Article
- A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates.NPJ vaccines · 2021Article
- Rhesus macaques as a tractable physiological model of human ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Dissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry.Clinical immunology (Orlando, Fla.) · 2019Article
- Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease.Frontiers in aging neuroscience · 2018Review
- Androgen supplementation improves some but not all aspects of immune senescence in aged male macaques.GeroScience · 2017Article
- Age, but not anthelmintic treatment, is associated with urinary neopterin levels in semi-free ranging Barbary macaques.Scientific reports · 2017Article
- Fatty liver promotes fibrosis in monkeys consuming high fructose.Obesity (Silver Spring, Md.) · 2017Article
- Reduced Intestinal Motility, Mucosal Barrier Function, and Inflammation in Aged Monkeys.The journal of nutrition, health & aging · 2017Article
- Microbial translocation and skeletal muscle in young and old vervet monkeys.Age (Dordrecht, Netherlands) · 2016Article
- Contributions of Nonhuman Primates to Research on Aging.Veterinary pathology · 2016Review
- Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Using the pathogenic and nonpathogenic nonhuman primate model for studying non-AIDS comorbidities.Current HIV/AIDS reports · 2015Review
- Host sex and age influence endoparasite burdens in the gray mouse lemur.Frontiers in zoology · 2015Article
- Efficacy of influenza vaccination of elderly rhesus macaques is dramatically improved by addition of a cationic lipid/DNA adjuvant.The Journal of infectious diseases · 2014Article
- Age and immune status of rhesus macaques impact simian varicella virus gene expression in sensory ganglia.Journal of virology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Aging is accompanied by a general dysregulation in immune system function, commonly referred to as 'immune senescence'. This progressive deterioration affects both innate and adaptive immunity, although accumulating evidence indicates that the adaptive arm of the immune system may exhibit more profound changes. Most of our current understanding of immune senescence stems from clinical and rodent studies. More recently, the use of nonhuman primates (NHPs) to investigate immune senescence and test interventions aimed at delaying/reversing age-related changes in immune function has dramatically increased. These studies have been greatly facilitated by several key advances in our understanding of the immune system of old world monkeys, specifically the rhesus macaques. In this review we describe the hallmarks of immune senescence in this species and compare them to those described in humans. We also discuss the impact of immune senescence on the response to vaccination and the efficacy of immuno-restorative interventions investigated in this model system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.