Evidence map›Paper›PMID 20558014›Full record

ArticleDrug and alcohol dependence2010

Gender differences in the relationship of internalizing and externalizing psychopathology to alcohol dependence: likelihood, expression and course.

Deborah A Dawson, Risë B Goldstein, Howard B Moss, Ting-Kai Li, Bridget F Grant

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Prenatal drug exposure, behavioral problems, and drug experimentation among African-American urban adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2014
    Trial
  2. Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors.medRxiv : the preprint server for health sciences · 2025
    Article
  3. Article
  4. Comparative Analysis of Autistic Women Across the Lifespan: Childhood vs. Adulthood Diagnosis.Autism research : official journal of the International Society for Autism Research · 2025
    Article
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  12. A trait-like propensity to experience internalizing symptoms is associated with problem alcohol involvement across adulthood, but not adolescence.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
    Article
  13. Extra-striatal DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deborah A DawsonLaboratory of Epidemiology and Biometry, Division of Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA.
Risë B Goldstein
Howard B Moss
Ting-Kai Li
Bridget F Grant

Funding

National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) - IIIZIAAA000449 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GRANT, BRIDGET F · 2009 to 2016
$16.5M
Intramural NIH HHS Z99 AA999999
6 · The paper itself

Abstract

objectiveTo determine whether internalizing and externalizing psychopathology were differentially associated with alcohol dependence in men and women.

methodsFour categories of lifetime psychopathology were examined: neither internalizing nor externalizing (NINE), internalizing only (IO), externalizing only (EO) and both internalizing and externalizing (BIE). Multivariate models assessed gender differences in the adjusted associations of these categories with the odds of lifetime alcohol dependence in a representative sample of 43,093 U.S. adults 18 and older and with clinical course and expression in a subsample of 4781 lifetime alcoholics.

resultsThe excess odds of lifetime alcohol dependence associated with IO, EO and BIE were significantly greater for women than men, OR=2.6, 8.8 and 10.7 versus 1.9, 4.0 and 6.5, respectively. Regardless of gender, the ORs were significantly higher for EO than IO and for BIE than EO. Gender differences in the expression and course of alcoholism were most pronounced for the categories of NINE and IO, with men having greater consumption, dependence severity and treatment but less familial alcoholism. Gender variation in the association of psychopathology with the expression and course of alcoholism was most evident in the BIE category, where the associations were stronger for women. Lifetime externalizing psychopathology was associated with an increased likelihood of treatment utilization, especially among women.

conclusionsFindings highlight the need to increase alcoholism screening, prevention and intervention among women with psychopathology, especially externalizing. The greater numbers of internalizing than externalizing alcoholics emphasize the need to treat symptoms of depression and anxiety in alcohol treatment settings.

Indexed as

AdultAgedAged, 80 and overAlcohol DrinkingAlcoholismAnxiety DisordersCohort StudiesComorbidityDepressive DisorderFemaleHumansInterview, PsychologicalMaleMental DisordersMiddle AgedPrognosis

Identifiers

PMID20558014
PMCPMC2953598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.