ArticleJournal of proteome research2010
Gastric cancer-specific protein profile identified using endoscopic biopsy samples via MALDI mass spectrometry.
Article in Journal of proteome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Data-independent acquisition (DIA) mass spectrometry reveals related proteins involved in the occurrence of early intestinal-type gastric cancer.Medical oncology (Northwood, London, England) · 2023Article
- Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2023Article
- A Novel Overall Survival Prediction Signature Based on Comprehensive Research in Prostate Cancer Bone Metastases.Frontiers in medicine · 2022Article
- Multiclass cancer classification in fresh frozen and formalin-fixed paraffin-embedded tissue by DigiWest multiplex protein analysis.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review.International journal of molecular sciences · 2017Review
- What gastric cancer proteomic studies show about gastric carcinogenesis?Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Differentially expressed proteins among normal cervix, cervical intraepithelial neoplasia and cervical squamous cell carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2015Article
- Mass spectrometry-based methods for identifying oxidized proteins in disease: advances and challenges.Biomolecules · 2015Review
- Proteomic and metabolic prediction of response to therapy in gastric cancer.World journal of gastroenterology · 2014Review
- Perspectives on new biomarkers in gastric cancer: diagnostic and prognostic applications.World journal of gastroenterology · 2014Review
- Mass spectrometry of natural products: current, emerging and future technologies.Natural product reports · 2014Review
- Discovery and validation of an INflammatory PROtein-driven GAstric cancer Signature (INPROGAS) using antibody microarray-based oncoproteomics.Oncotarget · 2014Article
- Comprehensive identification of proteins from MALDI imaging.Molecular & cellular proteomics : MCP · 2013Article
- Availability of MudPIT data for classification of biological samples.Journal of clinical bioinformatics · 2013Article
- Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas.British journal of cancer · 2012Article
- Article
- Analysis of cancer tissues by means of spectroscopic methods.Contemporary oncology (Poznan, Poland) · 2012Article
- MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer.The American journal of pathology · 2011Article
- Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype.BMC cancer · 2011Article
- MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications.Histochemistry and cell biology · 2011Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
To date, proteomic analyses on gastrointestinal cancer tissue samples have been performed using surgical specimens only, which are obtained after a diagnosis is made. To determine if a proteomic signature obtained from endoscopic biopsy samples could be found to assist with diagnosis, frozen endoscopic biopsy samples collected from 63 gastric cancer patients and 43 healthy volunteers were analyzed using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. A statistical classification model was developed to distinguish tumor from normal tissues using half the samples and validated with the other half. A protein profile was discovered consisting of 73 signals that could classify 32 cancer and 22 normal samples in the validation set with high predictive values (positive and negative predictive values for cancer, 96.8% and 91.3%; sensitivity, 93.8%; specificity, 95.5%). Signals overexpressed in tumors were identified as alpha-defensin-1, alpha-defensin-2, calgranulin A, and calgranulin B. A protein profile was also found to distinguish pathologic stage Ia (pT1N0M0) samples (n = 10) from more advanced stage (Ib or higher) tumors (n = 48). Thus, protein profiles obtained from endoscopic biopsy samples may be useful in assisting with the diagnosis of gastric cancer and, possibly, in identifying early stage disease.
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