ArticleCellular and molecular life sciences : CMLS2010
Co-chaperones are limiting in a depleted chaperone network.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
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- Proteome-Wide Mapping of Artesunate Targets Reveals Enrichment of the Ubiquitin-Proteasome System.Drug design, development and therapy · 2025Article
- Beneficial mechanisms of dimethyl fumarate in autoimmune uveitis: insights from single-cell RNA sequencing.Journal of neuroinflammation · 2024Article
- Telomerase promotes formation of a telomere protective complex in cancer cells.Science advances · 2019Article
- Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains.ACS synthetic biology · 2018Article
- Transcriptomic profiles of the bovine mammary gland during lactation and the dry period.Functional & integrative genomics · 2018Article
- Review
- Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity.Disease models & mechanisms · 2016Review
- Optimization of expression and purification of HSPA6 protein from Camelus dromedarius in E. coli.Saudi journal of biological sciences · 2016Article
- Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1.ACS chemical biology · 2016Article
- Spectroscopic and thermodynamic properties of recombinant heat shock protein A6 from Camelus dromedarius.European biophysics journal : EBJ · 2015Article
- Article
- Tumor suppressive microRNA-193b promotes breast cancer progression via targeting DNAJC13 and RAB22A.International journal of clinical and experimental pathology · 2014Article
- A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant.Cell stress & chaperones · 2013Article
- Pseudophosphorylated αB-crystallin is a nuclear chaperone imported into the nucleus with help of the SMN complex.PloS one · 2013Article
- Heat shock factor 1 is inactivated by amino acid deprivation.Cell stress & chaperones · 2012Article
- Protein refolding in peroxisomes is dependent upon an HSF1-regulated function.Cell stress & chaperones · 2012Article
- Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy.Annals of neurology · 2012Article
- Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1.The EMBO journal · 2012Article
- A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To probe the limiting nodes in the chaperoning network which maintains cellular proteostasis, we expressed a dominant negative mutant of heat shock factor 1 (dnHSF1), the regulator of the cytoplasmic proteotoxic stress response. Microarray analysis of non-stressed dnHSF1 cells showed a two- or more fold decrease in the transcript level of 10 genes, amongst which are the (co-)chaperone genes HSP90AA1, HSPA6, DNAJB1 and HSPB1. Glucocorticoid signaling, which requires the Hsp70 and the Hsp90 folding machines, was severely impaired by dnHSF1, but fully rescued by expression of DNAJA1 or DNAJB1, and partially by ST13. Expression of DNAJB6, DNAJB8, HSPA1A, HSPB1, HSPB8, or STIP1 had no effect while HSP90AA1 even inhibited. PTGES3 (p23) inhibited only in control cells. Our results suggest that the DNAJ co-chaperones in particular become limiting in a depleted chaperoning network. Our results also suggest a difference between the transcriptomes of cells lacking HSF1 and cells expressing dnHSF1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.