ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2010
Quantifying antibiotic use in paediatrics: a proposal for neonatal DDDs.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metrics for quantifying antibiotic use in the hospital setting: results from a systematic review and international multidisciplinary consensus procedure.The Journal of antimicrobial chemotherapy · 2018Pooled it
- From Screening to Outcomes: Fourteen-Year Hospital-Wide Surveillance of Alert Pathogens and Antimicrobial Use in a Paediatric Tertiary Hospital.Antibiotics (Basel, Switzerland) · 2026Article
- Antimicrobial Use Monitoring in Neonatal Population Using a Defined Daily Doses Method.Neonatology · 2026Observational
- Monitoring of pediatric antibiotic consumption using electronic medical records in an Italian tertiary care hospital.Scientific reports · 2025Article
- Study of antibiotic consumption using a novel unit among indoor pediatric patients in India.Bioinformation · 2025Article
- Profile of antimicrobial use and potential use of the defined daily dose in neonatology.Scientific reports · 2024Article
- Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013-2020.Infection · 2024Article
- Assessment of Antimicrobial Consumption in Multi-Field Hospitals with Pediatric Inpatients: Conventional vs. Novel Pediatric-Adjusted Methodologies.Antibiotics (Basel, Switzerland) · 2023Article
- Antimicrobial Defined Daily Dose in Neonatal Population: Validation in the Clinical Practice.Antibiotics (Basel, Switzerland) · 2023Article
- Development of Antimicrobial Defined Daily Dose (DDD) for the Pediatric Population.Antibiotics (Basel, Switzerland) · 2023Article
- Prescribed daily-dose-based metrics of oral antibiotic use for hospitalized children in Japan.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Use of multiple metrics to assess antibiotic use in Italian children's hospitals.Scientific reports · 2021Article
- A Novel Metric System to Quantify Antibiotic Consumption in Paediatric Population: A Hospital Based, Biphasic Pilot Study.Discoveries (Craiova, Romania) · 2020Article
- Antibiotic prescribing trends in a pediatric population in Lithuania in 2003-2012: Observational study.Medicine · 2019Observational
- Rational Use of Antibiotics in Neonates: Still in Search of Tailored Tools.Healthcare (Basel, Switzerland) · 2019Review
- Comparison of antibiotic dosing recommendations for neonatal sepsis from established reference sources.International journal of clinical pharmacy · 2018Article
- Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland.Annals of clinical microbiology and antimicrobials · 2017Article
- Drug Utilization on Neonatal Wards: A Systematic Review of Observational Studies.Frontiers in pharmacology · 2017Article
- Challenges in measuring antibiotic consumption.Current infectious disease reports · 2013Article
- A 10-year analysis of the effects of media coverage of regulatory warnings on antidepressant use in The Netherlands and UK.PloS one · 2012Article
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4 authors.
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Abstract
The defined daily dose (DDD) as defined by the World Health Organization (WHO) has been the most frequently used unit of measurement to measure antibiotic use. However, measuring antibiotic use in paediatrics is a problem as the WHO DDD methodology is not applicable in children (aged >1 month) due to the large variation in body weight within this population. Based on the narrow range of body weights in the neonatal population, we therefore aimed to develop a set of neonatal DDDs for antibiotics. Eight well-respected (inter)national sources for dosage recommendations of antibiotics in children and neonates were consulted for the assumed maintenance dose of the ten most frequently used antibiotics in neonatal intensive care units in its main indication for neonates. A set of neonatal DDDs for ten commonly used antibiotics in neonates based on an assumed neonatal weight of 2 kg was proposed. Primarily in children DDDs are not applicable to quantify antibiotic use since there is large variation in body weight. In the neonatal population, however, based on its narrow range of body weights and when access to patient level data is not available, neonatal DDDs can be used as a unit of measurement.
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