ArticlePediatric nephrology (Berlin, Germany)2010
Outcome and management of isolated severe renal pelvis dilatation detected at postnatal screening.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 34 citations in OpenAlex.
- The Diagnostic Efficacy of and Requirement for Postnatal Ultrasonography Screening for Congenital Anomalies of the Kidney and Urinary Tract.Diagnostics (Basel, Switzerland) · 2023Article
- [Congenital dilatation of the upper urinary tract : Current diagnostic and treatment concepts].Der Urologe. Ausg. A · 2018Article
- Article
- Children and adolescents with ureteropelvic junction obstruction: is an additional voiding cystourethrogram necessary? Results of a multicenter study.World journal of urology · 2013Article
- Clinical importance of pyelocalyceal dilation diagnosed by postnatal ultrasonographic screening of the urinary tract.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Early risk factors for neonatal mortality in CAKUT: analysis of 524 affected newborns.Pediatric nephrology (Berlin, Germany) · 2012Article
- Antibiotic prophylaxis in antenatal nonrefluxing hydronephrosis, megaureter and ureterocele.Nature reviews. Urology · 2012Review
- Response to: Hydronephrosis due to pelviureteric junction narrowing: Utility of urinary enzymes to predict the need for surgical management and follow up.Journal of Indian Association of Pediatric Surgeons · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the incidence and outcome of isolated severe renal pelvis dilatation (RPD; APD>15<or=20 mm) in an unselected population of 2-month-old infants prospectively followed up for 12-14 months of life. Isolated severe renal pelvis dilatation was detected in 46 of the 11,801 (0.39%) infants screened. Nephro-urological investigations were initiated if RPD persisted, or if urinary tract infection (UTI) occurred during follow-up, and antibiotic therapy was administered only when UTI occurred. At follow-up, RPD persisted in 24 infants. Of these, 8 infants presented with vesico-ureteral reflux (VUR) of grade>or=3 and 16 with ureteropelvic junction obstruction (UPJO). Incidence of UTI was significantly higher (p<0.001) in infants of the study group than in infants of the control group (13.9 vs 2.5%). Our data suggest that isolated severe RPD may be a self-limiting condition and that antibiotic prophylaxis (AP) for the prevention of UTI should not be performed. Considering RDP resolution and the incidence of UTI during follow-up, investigations for uropathy in infants with isolated, severe RPD are justified in persistent cases, or when UTI occurs during follow-up. Careful clinical monitoring for signs of UTI and treatment of each episode of UTI may be sufficient and safe.
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