ArticleThe Korean journal of pain2010
Pharmacologic management of chronic pain.
Article in The Korean journal of pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The trial behind it
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Who cites it
35 citing papers in PubMed, 117 citations in OpenAlex.
- Analgesic Efficacy and Safety of Prolonged-Release Oxycodone/Naloxone in Korean Patients with Chronic Pain from Spinal Disorders.Clinics in orthopedic surgery · 2018Trial
- Non-Invasive Brain Stimulation for Core Symptoms of Chronic Primary Pain: A Meta-Analysis of RCTs.Brain sciences · 2026Review
- The paraEuropean journal of pain (London, England) · 2026Article
- Article
- CYP2D6 Pharmacogenetics in Nigerian Sickle Cell Disease: Phase 1 of Implementing Pharmacogenomics Testing for Effective Care and Treatment in Africa (iPROTECTA) program.Gates open research · 2025Article
- Explainable fNIRS-based pain decoding under pharmacological conditions via deep transfer learning approach.Neurophotonics · 2024Article
- Pain-Insomnia-Depression Syndrome: Triangular Relationships, Pathobiological Correlations, Current Treatment Modalities, and Future Direction.Pain and therapy · 2024Review
- The effect of perineural injection therapy on neuropathic pain: a retrospective study.Journal of dental anesthesia and pain medicine · 2024Article
- Neuromodulation Techniques in Chronic Refractory Coccydynia: A Narrative Review.Pain and therapy · 2024Review
- A Critical Involvement of Glutamatergic Neurons in the Anterior Insular Cortex for Subdiaphragmatic Vagotomy-induced Analgesia.Experimental neurobiology · 2023Article
- Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions.The journal of pain · 2023Article
- Painful to Discuss: The Intersection of Chronic Pain, Mental Health, and Analgesic Use among People with HIV.Journal of AIDS and HIV treatment · 2023Article
- High-impact chronic pain: evaluation of risk factors and predictors.The Korean journal of pain · 2023Article
- Conolidine: A Novel Plant Extract for Chronic Pain.Anesthesiology and pain medicine · 2021Review
- Serotonin syndrome in a patient with chronic pain taking analgesic drugs mistaken for psychogenic nonepileptic seizure: a case report.Yeungnam University journal of medicine · 2021Article
- Ketamine for the Treatment of Chronic Pain: A Comprehensive Review.Health psychology research · 2021Review
- Non-Opioid Perioperative Pain Strategies for the Clinician: A Narrative Review.Pain and therapy · 2020Review
- Article
- Medicolegal Consideration to Prevent Medical Malpractice Regarding Opioid Administration: An Analysis of Judicial Opinion in South Korea.Journal of pain research · 2020Article
- Therapeutic alternatives in painful diabetic neuropathy: a meta-analysis of randomized controlled trials.The Korean journal of pain · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain is a multifactorial condition with both physical and psychological symptoms, and it affects around 20% of the population in the developed world. In spite of outstanding advances in pain management over the past decades, chronic pain remains a significant problem. This article provides a mechanism- and evidence-based approach to improve the outcome for pharmacologic management of chronic pain. The usual approach to treat mild to moderate pain is to start with a nonopioid analgesic. If this is inadequate, and if there is an element of sleep deprivation, then it is reasonable to add an antidepressant with analgesic qualities. If there is a component of neuropathic pain or fibromyalgia, then a trial with one of the gabapentinoids is appropriate. If these steps are inadequate, then an opioid analgesic may be added. For moderate to severe pain, one would initiate an earlier trial of a long term opioid. Skeletal muscle relaxants and topicals may also be appropriate as single agents or in combination. Meanwhile, the steps of pharmacologic treatments for neuropathic pain include (1) certain antidepressants (tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors), calcium channel alpha(2)-delta ligands (gabapentin and pregabalin) and topical lidocaine, (2) opioid analgesics and tramadol (for first-line use in selected clinical circumstances) and (3) certain other antidepressant and antiepileptic medications (topical capsaicin, mexiletine, and N-methyl-d-aspartate receptor antagonists). It is essential to have a thorough understanding about the different pain mechanisms of chronic pain and evidence-based multi-mechanistic treatment. It is also essential to increase the individualization of treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.