ArticleAmerican journal of physiology. Cell physiology2010
Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues.
Article in American journal of physiology. Cell physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
115 citing papers in PubMed, 1 synthesis or guideline pooled it, 231 citations in OpenAlex.
- Epidemiological and mechanistic links between PMFrontiers in endocrinology · 2025Pooled it
- Diabetes mellitus is associated with hepatocellular carcinoma: a retrospective case-control study in hepatitis endemic area.PloS one · 2013Trial
- Immune, inflammatory, and metal biomarker profiles in chronic respiratory diseases receiving oligo-fucoidan under ambient PM₂.₅ exposure.Scientific reports · 2026Article
- Ultrafine particulate matter exposure induces gut microbiota dysbiosis together with ER stress in the liver and worsened atherosclerosis.Environment international · 2026Article
- Molecular mechanisms of air pollution-induced carcinogenesis and the emerging role of microplastics.Human genomics · 2025Review
- The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases.FEBS letters · 2025Review
- Endoplasmic Reticulum Stress and Unfolded Protein Response Sensor ERN1 Regulates Organic Dust Induction of Lung Inflammation.FASEB bioAdvances · 2025Article
- Neuroimmune axis: Linking environmental factors to pancreatic β-cell dysfunction in Diabetes.Brain, behavior, & immunity - health · 2025Article
- Inhalation exposure to airborne PMAmerican journal of physiology. Cell physiology · 2025Article
- Integrated hepatic transcriptomics and metabolomics identify Pck1 as a key factor in the broad dysregulation induced by vehicle pollutants.Particle and fibre toxicology · 2024Article
- Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies.Antioxidants (Basel, Switzerland) · 2024Review
- Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Environmental PMeGastroenterology · 2024Article
- Air pollution exposure and cardiometabolic risk.The lancet. Diabetes & endocrinology · 2024Review
- Air pollutants and primary liver cancer mortality: a cohort study in crop-burning activities and forest fires area.Frontiers in public health · 2024Article
- Quercetin alleviates PMPeerJ · 2024Article
- Air pollution, glymphatic impairment, and Alzheimer's disease.Trends in neurosciences · 2023Review
- Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1α/NOD1/NF‑κB pathway.International journal of molecular medicine · 2023Article
- PMBMJ open diabetes research & care · 2023Article
55 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Recent studies have suggested a link between inhaled particulate matter (PM) exposure and increased mortality and morbidity associated with pulmonary and cardiovascular diseases. However, a precise understanding of the biological mechanism underlying PM-associated toxicity and pathogenesis remains elusive. Here, we investigated the impact of PM exposure in intracellular stress signaling pathways with animal models and cultured cells. Inhalation exposure of the mice to environmentally relevant fine particulate matter (aerodynamic diameter < 2.5 μm, PM(2.5)) induces endoplasmic reticulum (ER) stress and activation of unfolded protein response (UPR) in the lung and liver tissues as well as in the mouse macrophage cell line RAW264.7. Ambient PM(2.5) exposure activates double-strand RNA-activated protein kinase-like ER kinase (PERK), leading to phosphorylation of translation initiation factor eIF2α and induction of C/EBP homologous transcription factor CHOP/GADD153. Activation of PERK-mediated UPR pathway relies on the production of reactive oxygen species (ROS) and is critical for PM(2.5)-induced apoptosis. Furthermore, PM(2.5) exposure can activate ER stress sensor IRE1α, but it decreases the activity of IRE1α in splicing the mRNA encoding the UPR trans-activator X-box binding protein 1 (XBP1). Together, our study suggests that PM(2.5) exposure differentially activates the UPR branches, leading to ER stress-induced apoptosis through the PERK-eIF2α-CHOP UPR branch. This work provides novel insights into the cellular and molecular basis by which ambient PM(2.5) exposure elicits its cytotoxic effects that may be related to air pollution-associated pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.