Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Concurrent glucocorticoid and noradrenergic activity shifts instrumental behavior from goal-directed to habitual control.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 149 citations in OpenAlex.
- Risky decision-making in the balloon analogue risk task - the role of noradrenaline and cortisol.Psychopharmacology · 2026Trial
- The effects of suppressing the biological stress systems on social threat-assessment following acute stress.Psychopharmacology · 2020Trial
- I'm going to fail! Acute cognitive performance anxiety increases threat-interference and impairs WM performance.PloS one · 2019Trial
- Combined Effects of Glucocorticoid and Noradrenergic Activity on Loss Aversion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Blocking the mineralocorticoid receptor in humans prevents the stress-induced enhancement of centromedial amygdala connectivity with the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Simultaneous glucocorticoid and noradrenergic activity disrupts the neural basis of goal-directed action in the human brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- An acute psychosocial stressor increases drinking in non-treatment-seeking alcoholics.Psychopharmacology · 2011Trial
- Neural Bases of Affect-Based Impulsivity: A Decision Neuroscience Account.Computational psychiatry (Cambridge, Mass.) · 2026Review
- Article
- Basal cortisol level modulates stress-induced opioid-seeking behavior.Neurobiology of stress · 2024Article
- Enhanced Risky Choice in Male Rats Elicited by the Acute Pharmacological Stressor Yohimbine Involves Prefrontal Dopamine D1 Receptor Activation.The international journal of neuropsychopharmacology · 2024Article
- Stress, associative learning, and decision-making.Neurobiology of learning and memory · 2023Review
- Communicative roots of complex sociality and cognition: neuropsychological mechanisms underpinning the processing of social information.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Stress diminishes outcome but enhances response representations during instrumental learning.eLife · 2022Article
- Examining the effect of stress on the flexible updating of avoidance responses.The European journal of neuroscience · 2022Article
- Chronic corticosterone administration in adolescence enhances dorsolateral striatum-dependent learning in adulthood.Frontiers in behavioral neuroscience · 2022Article
- Dopaminergic and noradrenergic modulation of stress-induced alterations in brain activation associated with goal-directed behaviour.Journal of psychopharmacology (Oxford, England) · 2021Article
- Dichotic listening performance and interhemispheric integration after administration of hydrocortisone.Scientific reports · 2021Article
- Physiological and subjective validation of a novel stress procedure: The Simple Singing Stress Procedure.Behavior research methods · 2021Article
- Experimentally induced and real-world anxiety have no demonstrable effect on goal-directed behaviour.Psychological medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress modulates instrumental action in favor of habitual stimulus-response processes that are insensitive to changes in outcome value and at the expense of goal-directed action-outcome processes. The neuroendocrine mechanism underlying this phenomenon is unknown. Here, we tested the hypothesis that concurrent glucocorticoid and noradrenergic activity bias instrumental behavior toward habitual performance. To this end, healthy men and women received hydrocortisone, the alpha2-adrenoceptor antagonist yohimbine or both orally before they were trained in two instrumental actions leading to two distinct food outcomes. After training, one of the outcomes was devalued by inviting participants to eat that food to satiety. A subsequent extinction test revealed whether instrumental performance was goal-directed or habitual. Participants that received hydrocortisone or yohimbine alone decreased responding to the devalued action in the extinction test, i.e., they behaved goal-directed. The combined administration of hydrocortisone and yohimbine, however, rendered participants' behavior insensitive to changes in the value of the goal (i.e., habitual). These findings demonstrate that the concerted action of glucocorticoids and noradrenergic activity shifts instrumental behavior from goal-directed to habitual control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.