Evidence map›Paper›PMID 20554772›Full record

ArticleJournal of virology2010

Genetic diversity and histo-blood group antigen interactions of rhesus enteric caliciviruses.

Tibor Farkas, Robert W Cross, Edwin Hargitt, Nicholas W Lerche, Ardythe L Morrow, Karol Sestak

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 131 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Tibor FarkasDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. Tibor.Farkas@cchmc.org
Robert W Cross
Edwin Hargitt
Nicholas W Lerche
Ardythe L Morrow
Karol Sestak
Cincinnati Children's Hospital Medical Center · USTulane University · USUniversity of California, Davis · USUniversity of Cincinnati Medical Center · US

Funding

ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONSP51RR000164 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI MARX, PRESTON A · 1985 to 2011
$100.1M
VIRAL GASTROENTERITIS PATHOGENSP01HD013021 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MORROW, ARDYTHE L · 1985 to 2013
$15.0M
ENTERIC VIRAL INFECTIONS OF CAPTIVE RHESUS MACAQUESR21RR024871 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI SESTAK, KAROL · 2008 to 2009
$379k
NCRR NIH HHS P51 RR000164NCRR NIH HHS P51RR000164-47NCRR NIH HHS R21 RR024871NCRR NIH HHS R21RR024871NICHD NIH HHS HD013021NICHD NIH HHS P01 HD013021
6 · The paper itself

Abstract

Recently, we reported the discovery and characterization of Tulane virus (TV), a novel rhesus calicivirus (CV) (T. Farkas, K. Sestak, C. Wei, and X. Jiang, J. Virol. 82:5408-5416, 2008). TV grows well in tissue culture, and it represents a new genus within Caliciviridae, with the proposed name of Recovirus. We also reported a high prevalence of CV antibodies in macaques of the Tulane National Primate Research Center (TNPRC) colony, including anti-norovirus (NoV), anti-sapovirus (SaV), and anti-TV (T. Farkas, J. Dufour, X. Jiang, and K. Sestak, J. Gen. Virol. 91:734-738, 2010). To broaden our knowledge about CV infections in captive nonhuman primates (NHP), 500 rhesus macaque stool samples collected from breeding colony TNPRC macaques were tested for CVs. Fifty-seven (11%) samples contained recovirus isolates. In addition, one NoV was detected. Phylogenetic analysis classified the recovirus isolates into two genogroups and at least four genetic types. The rhesus NoV isolate was closely related to GII human NoVs. TV-neutralizing antibodies were detected in 88% of serum samples obtained from primate caretakers. Binding and plaque reduction assays revealed the involvement of type A and B histo-blood group antigens (HBGA) in TV infection. Taken together, these findings indicate the zoonotic potential of primate CVs. The discovery of a genetically diverse and prevalent group of primate CVs and remarkable similarities between rhesus enteric CVs and human NoVs opens new possibilities for research involving in vitro and in vivo models of human NoV gastroenteritis.

Indexed as

Genetic VariationAnimalsAntibodies, NeutralizingAntibodies, ViralBlood Group AntigensCaliciviridaeCaliciviridae InfectionsFecesHumansMacaca mulattaMolecular Sequence DataPhylogenyAntibodies, NeutralizingAntibodies, ViralBlood Group Antigens

Identifiers

PMID20554772
PMCPMC2919043
OpenAlexW2077603141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.