ReviewCold Spring Harbor perspectives in biology2010
Closing the circle: replicating RNA with RNA.
Review in Cold Spring Harbor perspectives in biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Mixed anhydrides at the intersection between peptide and RNA autocatalytic sets: evolution of biological coding.Interface focus · 2023Article
- The Origin of Life: What Is the Question?Astrobiology · 2022Article
- Social Networking of Quasi-Species Consortia drive Virolution via Persistence.AIMS microbiology · 2021Review
- Thresholds in Origin of Life Scenarios.iScience · 2020Review
- Origin of Life: The Point of No Return.Life (Basel, Switzerland) · 2020Article
- Continuous nonenzymatic cross-replication of DNA strands withChemical science · 2019Article
- From molecular to cellular form: modeling the first major transition during the arising of life.BMC evolutionary biology · 2019Article
- Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code Through Origin of Life.Life (Basel, Switzerland) · 2018Article
- Oligomerization of a Bimolecular Ribozyme Modestly Rescues its Structural Defects that Disturb Interdomain Assembly to Form the Catalytic Site.Journal of molecular evolution · 2018Article
- What Does "the RNA World" Mean to "the Origin of Life"?Life (Basel, Switzerland) · 2017Article
- Tag mechanism as a strategy for the RNA replicase to resist parasites in the RNA world.PloS one · 2017Article
- Co-operation between Polymerases and Nucleotide Synthetases in the RNA World.PLoS computational biology · 2016Article
- Host-parasite oscillation dynamics and evolution in a compartmentalized RNA replication system.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Protocells: at the interface of life and non-life.Life (Basel, Switzerland) · 2015Article
- RNA synthesis by in vitro selected ribozymes for recreating an RNA world.Life (Basel, Switzerland) · 2015Review
- The RNA World: molecular cooperation at the origins of life.Nature reviews. Genetics · 2015Review
- An Interpretation of the Ancestral Codon from Miller's Amino Acids and Nucleotide Correlations in Modern Coding Sequences.Bioinformatics and biology insights · 2015Article
- Pragmatic turn in biology: From biological molecules to genetic content operators.World journal of biological chemistry · 2014Review
- Rethinking quasispecies theory: From fittest type to cooperative consortia.World journal of biological chemistry · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How life emerged on this planet is one of the most important and fundamental questions of science. Although nearly all details concerning our origins have been lost in the depths of time, there is compelling evidence to suggest that the earliest life might have exploited the catalytic and self-recognition properties of RNA to survive. If an RNA based replicating system could be constructed in the laboratory, it would be much easier to understand the challenges associated with the very earliest steps in evolution and provide important insight into the establishment of the complex metabolic systems that now dominate this planet. Recent progress into the selection and characterization of ribozymes that promote nucleotide synthesis and RNA polymerization are discussed and outstanding problems in the field of RNA-mediated RNA replication are summarized.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.