Trial reportArchives of neurology2010
Replication of CLU, CR1, and PICALM associations with alzheimer disease.
Trial report in Archives of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 12 syntheses or guidelines pooled it, 214 citations in OpenAlex.
- Correlation of PICALM polymorphism rs3851179 with Alzheimer's disease among Caucasian and Chinese populations: a meta-analysis and systematic review.Metabolic brain disease · 2018Pooled it
- Analyzing 74,248 Samples Confirms the Association Between CLU rs11136000 Polymorphism and Alzheimer's Disease in Caucasian But Not Chinese population.Scientific reports · 2018Pooled it
- Association between CLU gene rs11136000 polymorphism and Alzheimer's disease: an updated meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses.Oncotarget · 2016Pooled it
- CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations.Journal of neural transmission (Vienna, Austria : 1996) · 2015Pooled it
- The CLU gene rs11136000 variant is significantly associated with Alzheimer's disease in Caucasian and Asian populations.Neuromolecular medicine · 2014Pooled it
- Genome-wide association study of Alzheimer's disease with psychotic symptoms.Molecular psychiatry · 2012Pooled it
- Interleukin-1A -889C/T polymorphism and risk of Alzheimer's disease: a meta-analysis based on 32 case-control studies.Journal of neurology · 2012Pooled it
- Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population.American journal of Alzheimer's disease and other dementias · 2011Pooled it
- Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.Nature genetics · 2011Pooled it
- Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease.Human genetics · 2011Pooled it
- Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions.Journal of Alzheimer's disease : JAD · 2011Pooled it
- Neuroinflammation in Alzheimer disease.Nature reviews. Immunology · 2025Review
- Knowing the enemy: strategic targeting of complement to treat Alzheimer disease.Nature reviews. Neurology · 2025Review
- Single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease.Nature communications · 2024Article
- Comorbidity Genes of Alzheimer's Disease and Type 2 Diabetes Associated with Memory and Cognitive Function.International journal of molecular sciences · 2024Review
- Extracellular chaperone networks and the export of J-domain proteins.The Journal of biological chemistry · 2023Review
- The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders.Molecular neurobiology · 2022Review
- Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer's Disease.Frontiers in aging neuroscience · 2022Review
- Defects of Nutrient Signaling and Autophagy in Neurodegeneration.Frontiers in cell and developmental biology · 2022Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease.
designFollow-up case-control association study.
settingThe Mayo Clinics at Jacksonville, Florida, and Rochester, Minnesota.
participantsCommunity-based patients of European descent with late-onset Alzheimer disease (LOAD) and controls without dementia who were seen at the Mayo clinics, and autopsy-confirmed cases and controls whose pathology was evaluated at the Mayo Clinic in Jacksonville. Additional samples were obtained from the National Cell Repository for Alzheimer Disease (NCRAD). A total of 1829 LOAD cases and 2576 controls were analyzed.
interventionsThe most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. Main Outcome Measure Clinical or pathology-confirmed diagnosis of LOAD.
resultsOdds ratios for CLU, CR1, and PICALM were 0.82, 1.15, and 0.80, respectively, comparable in direction and magnitude with those originally reported. P values were 8.6 x 10(-5), .014, and 1.3 x 10(-5), respectively; they remain significant even after Bonferroni correction for the 3 single-nucleotide polymorphisms tested.
conclusionThese results show near-perfect replication and provide the first additional evidence that CLU, CR1, and PICALM are associated with the risk of LOAD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.