Evidence map›Paper›PMID 20554470›Full record

ArticleTrends in cognitive sciences2010

Dynamic Network Connectivity: A new form of neuroplasticity.

Amy F T Arnsten, Constantinos D Paspalas, Nao J Gamo, Yang Yang, Min Wang

Open access · greenAbstract read
In one paragraph

Article in Trends in cognitive sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.

  1. Pooled it
  2. Concomitant activation of DResearch square · 2026
    Article
  3. Concomitant activation of DDiscover pharmaceutical sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Dynamic Network Connectivity: from monkeys to humans.Frontiers in human neuroscience · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  17. Review
  18. Review
  19. Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amy F T ArnstenDepartment Neurobiology, Yale Medical School, 333 Cedar St., New Haven, CT 06510, USA. amy.arnsten@yale.edu
Constantinos D Paspalas
Nao J Gamo
Yang Yang
Min Wang
Yale University · US

Funding

PHARMACOLOGICAL PROTECTION OF AGING PREFRONTAL CORTICAL NETWORKSP01AG030004 · NIA · YALE UNIVERSITY · PI ARNSTEN, AMY F.T. · 2008 to 2012
$9.0M
COGNITIVE LOSS WITH AGE--ROLE OF CORTICAL CATECHOLAMINESR37AG006036 · NIA · YALE UNIVERSITY · PI ARNSTEN, AMY F.T. · 1998 to 2007
$3.0M
Ionic and Second Messanger Basis of Stress-Induced Prefrontal Dysfunction (#2 ofRL1AA017536 · NIAAA · YALE UNIVERSITY · PI ARNSTEN, AMY F.T. · 2007 to 2011
$1.8M
COGNITIVE LOSS WITH AGE: ROLE OF CORTICAL CATECHOLAMINESR01AG006036 · NIA · YALE UNIVERSITY · PI ARNSTEN, AMY F.T. · 1986 to 1997
–
NCRR NIH HHS U54RR024350NIAAA NIH HHS 1RL1AA017536NIAAA NIH HHS RL1 AA017536NIA NIH HHS AG06036NIA NIH HHS P01 AG030004NIA NIH HHS R01 AG006036NIA NIH HHS R37 AG006036
6 · The paper itself

Abstract

Prefrontal cortical (PFC) working memory functions depend on pyramidal cell networks that interconnect on dendritic spines. Recent research has revealed that the strength of PFC network connections can be rapidly and reversibly increased or decreased by molecular signaling events within slender, elongated spines: a process we term Dynamic Network Connectivity (DNC). This newly discovered form of neuroplasticity provides great flexibility in mental state, but also confers vulnerability and limits mental capacity. A remarkable number of genetic and/or environmental insults to DNC signaling cascades are associated with cognitive disorders such as schizophrenia and age-related cognitive decline. These insults can dysregulate network connections and erode higher cognitive abilities, leading to symptoms such as forgetfulness, susceptibility to interference, and disorganized thought and behavior.

Indexed as

Models, NeurologicalNeural Networks, ComputerNonlinear DynamicsAgingAnimalsCognition DisordersDopamineHumansNeural PathwaysNeuronal PlasticityNeuronsPrefrontal CortexSchizophreniaDopamine

Identifiers

PMID20554470
PMCPMC2914830
OpenAlexW2034673701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.