ArticleVirology2010
High-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays.
Article in Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 37 citations in OpenAlex.
- Serum profiling of the antibody response to HPV in women with or without abnormal cervical cytology undergoing cervical cancer screening.Frontiers in immunology · 2025Article
- Serum Antibodies Against the E5 Oncoprotein from Human Papillomavirus Type 16 Are Inversely Associated with the Infection and the Degree of Cervical Lesions.Biomedicines · 2024Article
- Generating human papillomavirus (HPV) reference databases to maximize genomic mapping.Archives of virology · 2022Article
- Developments and Applications of Functional Protein Microarrays.Molecular & cellular proteomics : MCP · 2020Review
- Serum anti-GAPDH autoantibody levels reflect the severity of cervical lesions: A potential serum biomarker for cervical cancer screening.Oncology letters · 2019Article
- Rapid immunodiagnostics of multiple viral infections in an acoustic microstreaming device with serum and saliva samples.Lab on a chip · 2019Article
- Profiling of serum antibodies against human papillomavirus antigens in Korean women with cervical intraepithelial neoplasia and cervical cancer.Cancer medicine · 2018Article
- Serum Immune Profiling for Early Detection of Cervical Disease.Theranostics · 2017Article
- Characterization of rubella-specific humoral immunity following two doses of MMR vaccine using proteome microarray technology.PloS one · 2017Article
- Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) Web-Server.Scientific reports · 2016Article
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- A systems biology approach for diagnostic and vaccine antigen discovery in tropical infectious diseases.Current opinion in infectious diseases · 2015Review
- HPV16 antibodies as risk factors for oropharyngeal cancer and their association with tumor HPV and smoking status.Oral oncology · 2015Article
- Profiling of measles-specific humoral immunity in individuals following two doses of MMR vaccine using proteome microarrays.Viruses · 2015Article
- Systematic reference sample generation for multiplexed serological assays.Scientific reports · 2013Article
- Malaria vaccines: high-throughput tools for antigens discovery with potential for their development.Colombia medica (Cali, Colombia) · 2013Review
- Overview of protein microarrays.Current protocols in protein science · 2013Review
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
We have developed microarrays with all eight proteins encoded by 13 different human papillomavirus types associated with anogenital cancer (HPV-16, -18, -31, -33, -35, -45, and -53), genital warts (HPV-6 and -11), or skin lesions (HPV-1, -2, -4, and -5). We analyzed the seroprevalence of antibodies in 546 patients, which had either cervical carcinomas, or precursor lesions, or which were asymptomatic. All patient groups contained sera ranging from high reactivity against multiple HPV proteins to low or no reactivity. Computational analyses showed the E7 proteins of carcinogenic HPV types as significantly more reactive in cancer patients compared to asymptomatic individuals and discriminating between cancer and HSIL or LSIL patients. Antibodies against E4 and E5 had the highest seroprevalence but did not exhibit differential reactivity relative to pathology. Our study introduces a new approach to future evaluation of the overall antigenicity of HPV proteins and cross-reaction between homologous proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.