ReviewClinical psychology review2010
Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa.
Review in Clinical psychology review, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Distinct attention network topology and dynamics and their relations with pubertal hormones in preadolescent boys and girls with binge eating.Translational psychiatry · 2025Article
- Estrogenic Effect of Probiotics on Anxiety and Depression: A Narrative Review.International journal of molecular sciences · 2025Review
- Potential Differences in Psychedelic Actions Based on Biological Sex.Endocrinology · 2024Review
- The impact of estradiol on serotonin, glutamate, and dopamine systems.Frontiers in neuroscience · 2024Review
- Ovarian Hormones and Binge Eating in Adulthood: Summary of Findings and Implications for Individual Differences in Risk in Women.Current directions in psychological science · 2023Article
- Metabolic and feeding adjustments during pregnancy.Nature reviews. Endocrinology · 2023Review
- Gender and sex in eating disorders: A narrative review of the current state of knowledge, research gaps, and recommendations.Brain and behavior · 2023Review
- Sex differences in carcinoid syndrome: A gap to be closed.Reviews in endocrine & metabolic disorders · 2022Review
- The effects of puberty on associations between mood/personality factors and disordered eating symptoms in girls.The International journal of eating disorders · 2021Article
- Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Estrogen moderates genetic influences on binge eating during puberty: Disruption of normative processes?Journal of abnormal psychology · 2018Article
- Estrogenic suppression of binge-like eating elicited by cyclic food restriction and frustrative-nonreward stress in female rats.The International journal of eating disorders · 2017Article
- Differential Effects of Estrogen and Progesterone on Genetic and Environmental Risk for Emotional Eating in Women.Clinical psychological science : a journal of the Association for Psychological Science · 2016Article
- Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study.Psychological medicine · 2015Article
- Identified Serotonin-Releasing Neurons Induce Behavioral Quiescence and Suppress Mating in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle.The International journal of eating disorders · 2015Article
- Age differences in prenatal testosterone's protective effects on disordered eating symptoms: developmental windows of expression?Behavioral neuroscience · 2015Article
- Ovarian Hormone Influences on Dysregulated Eating: A Comparison of Associations in Women with versus without Binge Episodes.Clinical psychological science : a journal of the Association for Psychological Science · 2014Article
- Puberty as a critical risk period for eating disorders: a review of human and animal studies.Hormones and behavior · 2013Review
- [The effects of hormone replacement therapy on mind and brain].Der Nervenarzt · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Serotonergic dysregulation is thought to underlie much of the pathology in bulimia nervosa (BN). The purpose of this review is to expand the serotonergic model by incorporating specific and nonspecific contributions of estrogens to the development and maintenance of bulimic pathology in order to guide research from molecular genetics to novel therapeutics for BN. Special emphasis is given to the organizing theory of general brain arousal which allows for integration of specific and nonspecific effects of these systems on behavioral endpoints such as binge eating or purging as well as arousal states such as fear, novelty seeking, or sex. Regulation of the serotonergic system by estrogens is explored, and genetic, epigenetic, and environmental estrogen effects on bulimic pathology and risk factors are discussed. Genetic and neuroscientific research support this two-system conceptualization of BN with both contributions to the developmental and maintenance of the disorder. Implications of an estrogenic-serotonergic model of BN are discussed as well as guidelines and suggestions for future research and novel therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.