ArticleVirology2010
La Crosse virus (LACV) Gc fusion peptide mutants have impaired growth and fusion phenotypes, but remain neurotoxic.
Article in Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Replication competent La Crosse virus pseudotyped VSV vector system as vaccine and serological diagnostic reagent.Virus research · 2026Article
- Orthobunyavirus neurovirulence is a complex trait involving all three genome segments.bioRxiv : the preprint server for biology · 2025Article
- Research Progress on the Gc Proteins of Akabane Virus.Veterinary sciences · 2025Review
- Development of an RT-RPA assay for La Crosse virus detection provides insights into age-dependent neuroinvasion in mice.Virology journal · 2025Article
- The Role of Orthobunyavirus Glycoprotein Gc in the Viral Life Cycle: From Viral Entry to Egress.Molecules (Basel, Switzerland) · 2025Review
- The La Crosse virus class II fusion glycoproteinJournal of virology · 2023Article
- Arthropod-borne encephalitis: an overview for the clinician and emerging considerations.Postgraduate medical journal · 2023Review
- Article
- Article
- The Orthobunyavirus Germiston Enters Host Cells from Late Endosomes.Journal of virology · 2022Article
- Review
- Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines.Journal of neuroinflammation · 2018Article
- Early Bunyavirus-Host Cell Interactions.Viruses · 2016Review
- Development of Antiviral Innate Immunity During In Vitro Differentiation of Mouse Embryonic Stem Cells.Stem cells and development · 2016Article
- Antiviral responses in mouse embryonic stem cells: differential development of cellular mechanisms in type I interferon production and response.The Journal of biological chemistry · 2014Article
- Systems to establish bunyavirus genome replication in the absence of transcription.Journal of virology · 2013Article
- Mouse embryonic stem cells are deficient in type I interferon expression in response to viral infections and double-stranded RNA.The Journal of biological chemistry · 2013Article
- Orthobunyavirus entry into neurons and other mammalian cells occurs via clathrin-mediated endocytosis and requires trafficking into early endosomes.Journal of virology · 2012Article
- An assembly model of rift valley Fever virus.Frontiers in microbiology · 2012Article
- Arboviral encephalitides: transmission, emergence, and pathogenesis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
La Crosse virus is a leading cause of pediatric encephalitis in the Midwestern United States and an emerging pathogen in the American South. The LACV glycoprotein Gc plays a critical role in entry as the virus attachment protein. A 22 amino acid hydrophobic region within Gc (1066-1087) was recently identified as the LACV fusion peptide. To further define the role of Gc (1066-1087) in virus entry, fusion, and neuropathogenesis, a panel of recombinant LACV (rLACV) fusion peptide mutant viruses was generated. Replication of mutant rLACVs was significantly reduced. In addition, the fusion peptide mutants demonstrated decreased fusion phenotypes relative to LACV-WT. Interestingly, these viruses maintained their ability to cause neuronal loss in culture, suggesting that the fusion peptide of LACV Gc is a determinant of properties associated with neuroinvasion (growth to high titer in muscle cells and a robust fusion phenotype), but not necessarily of neurovirulence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.