ArticleDevelopmental biology2010
EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Sex-specific developmental gene expression atlas unveils dimorphic gene networks in C. elegans.Nature communications · 2024Article
- Long Non-Coding RNAInsects · 2022Article
- The Hox geneDevelopment (Cambridge, England) · 2019Article
- The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility.PLoS genetics · 2018Article
- Transcriptional control of non-apoptotic developmental cell death in C. elegans.Cell death and differentiation · 2016Article
- Cell-Specific mRNA Profiling of the Caenorhabditis elegans Somatic Gonadal Precursor Cells Identifies Suites of Sex-Biased and Gonad-Enriched Transcripts.G3 (Bethesda, Md.) · 2015Article
- Impacts of chronic low-level nicotine exposure on Caenorhabditis elegans reproduction: identification of novel gene targets.Reproductive toxicology (Elmsford, N.Y.) · 2013Article
- Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity.Nature reviews. Genetics · 2012Review
- The development of sexual dimorphism: studies of the Caenorhabditis elegans male.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Hox genes of the Abdominal-B (Abd-B) class regulate gonadal development in diverse metazoans. Here we have investigated the role of the Abd-B homolog egl-5 in C. elegans gonadal development. Previous work showed that egl-5 is required male-specifically in the gonad and that mutant gonads are highly dysgenic and possibly feminized. We have used sex-specific gonadal reporter genes to confirm that the gonads of egl-5 males are extensively feminized. Sex-specific expression of egl-5 requires the global sex determination gene tra-1 and the gonadal masculinizing gene fkh-6, but mutagenesis of a short male gonadal enhancer element in egl-5 suggested that this regulation is indirect. Ectopic expression of EGL-5 in hermaphrodites is sufficient to induce male gonadal gene expression, indicating that EGL-5 plays an instructive role in male gonadal fate determination. EGL-5 acts in parallel with a Wnt/beta-catenin pathway to regulate male gonadal fates and can physically interact with the Wnt pathway transcription factor POP-1 and modulate activity of a POP-1 dependent reporter gene. We propose that EGL-5 imparts sex-specific function on POP-1 by recruiting it to male-specific gonadal target genes.
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